1,2-Dithiolane-3-pentanamide, N-[4-(5-isoquinolinylamino)cyclohexyl]-

Request For Quotation
1,2-Dithiolane-3-pentanamide, N-[4-(5-isoquinolinylamino)cyclohexyl]- Suppliers list
Company Name: Guangzhou Younan Technology Co., Ltd  
Tel: 020-82000279 18988941452
Email: YN_research@163.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
1,2-Dithiolane-3-pentanamide, N-[4-(5-isoquinolinylamino)cyclohexyl]- Basic information
Product Name:1,2-Dithiolane-3-pentanamide, N-[4-(5-isoquinolinylamino)cyclohexyl]-
Synonyms:1,2-Dithiolane-3-pentanamide, N-[4-(5-isoquinolinylamino)cyclohexyl]-;PT109
CAS:2059104-90-2
MF:C23H31N3OS2
MW:429.64
EINECS:
Product Categories:
Mol File:2059104-90-2.mol
1,2-Dithiolane-3-pentanamide, N-[4-(5-isoquinolinylamino)cyclohexyl]- Structure
1,2-Dithiolane-3-pentanamide, N-[4-(5-isoquinolinylamino)cyclohexyl]- Chemical Properties
Boiling point 679.7±50.0 °C(Predicted)
density 1.23±0.1 g/cm3(Predicted)
pka15.86±0.40(Predicted)
Safety Information
MSDS Information
1,2-Dithiolane-3-pentanamide, N-[4-(5-isoquinolinylamino)cyclohexyl]- Usage And Synthesis
UsesPT109 is a multi-kinase inhibitor. PT109 inhibits JNK (JNK1: IC50=0.143 μM; JNK2: IC50=0.831 μM; JNK3: IC50=0.285 μM) and other kinases (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM; ROCK2: IC50=34 μM) and plays an important role in anti-inflammation, anti-oxidation, neurogenesis, synaptogenesis, etc. In addition, PT109 also reprograms glioblastoma multiforme (GBM) into oligodendrocytes through the PTBP1/PKM1/2 pathway and changes the metabolic pattern of GBM, exerting anti-glioma activity[1][2].
IC 50JNK1: 0.143 μM (IC50); JNK2: 0.831 μM (IC50); JNK3: 0.285 μM (IC50); SGK1: 1.34 μM (IC50); SGK3: 26.4 μM (IC50); ROCK2: 34 μM (IC50)
References[1] Chen Q, et al. Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo[J]. European Journal of Pharmacology, 2020, 883: 173361. DOI:10.1016/j.ejphar.2020.173361
[2] Yang Y, et al. PT109, a novel multi-kinase inhibitor suppresses glioblastoma multiforme through cell reprogramming: Involvement of PTBP1/PKM1/2 pathway[J]. European Journal of Pharmacology, 2022, 920: 174837. DOI:10.1016/j.ejphar.2022.174837
1,2-Dithiolane-3-pentanamide, N-[4-(5-isoquinolinylamino)cyclohexyl]- Preparation Products And Raw materials
Tag:1,2-Dithiolane-3-pentanamide, N-[4-(5-isoquinolinylamino)cyclohexyl]-(2059104-90-2) Related Product Information
ADAM8 Protein, MOUSE (HEK293, HIS) MMP-9 Protein, RAT (HEK293, HIS) Anti-Aging Compound Library MMP-2 Protein, HUMAN (HEK293, HIS) MMP-9 protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI) MMP-9 Protein, MOUSE (HEK293)