2-CHLOROPYRIMIDINE-4-CARBOXAMIDE manufacturers
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| | 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Basic information |
| | 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | solid | | Appearance | White to off-white Solid | | InChI | InChI=1S/C5H4ClN3O/c6-5-8-2-1-3(9-5)4(7)10/h1-2H,(H2,7,10) | | InChIKey | UXXQEVFRPLIOHJ-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=CC(C(N)=O)=N1 |
| | 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Usage And Synthesis |
| Chemical Properties | Light yellow solid | | Uses | 2-Chloropyrimidine-4-carboxamide is used as an organic synthesis and pharmaceutical intermediate. | | Synthesis | General procedure for the synthesis of 2-chloropyrimidine-4-carboxamide from 2-chloropyrimidine-4-carboxylic acid: 2-chloropyrimidine-4-carboxylic acid (500 mg, 1.00 eq.) was dissolved in thionyl chloride (10 mL) and the reaction was heated to 90 °C for 30 min. Upon completion of the reaction, the excess thionyl chloride was removed by concentration under reduced pressure. The residue was cooled to 0 °C and ammonium hydroxide solution (20 mL) was slowly added. The reaction mixture was extracted with dichloromethane (20 mL x 3), the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give 320 mg of 2-chloropyrimidine-4-carboxamide as a white solid. The product was analyzed by LC-MS (electrospray ionization, m/z): 158 [M+H]+. | | References | [1] Patent: WO2015/25026, 2015, A1. Location in patent: Page/Page column 209 |
| | 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Preparation Products And Raw materials |
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