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Wuhan ChemFaces Biochemical Co., Ltd.
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18607101326 15172504745 |
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aileen@chemfaces.com |
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Product Name:erythro-Austrobailignan-6
CAS:114127-24-1
Purity:>=98% Package:5mg ,10mg ,20mg ,50mg ,100mg; 200mg; 500mg,可根据客户需求定制 Remarks:1908/10mg
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| Company Name: |
Chengdu Push Bio-Technology Co., Ltd.
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028-028-85370565-229-229 18080489829 |
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3004654993@qq.com |
| Products Intro: |
Product Name:erythro-Austrobailignan-6
CAS:114127-24-1
Purity:95.0%（HPLC） Package:5mg
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| Company Name: |
Nanjing Digger Medical Technology Co. Ltd.
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| Tel: |
025-025-51191215 18013836722 |
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2399235533@qq.com |
| Products Intro: |
Product Name:erythro-Austrobailignan-6
CAS:114127-24-1
Purity:HPLC>=98% Package:20MG;100MG;500MG;1G;10G
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Phenol, 4-[(2R,3S)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxy-, rel- manufacturers
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| | Phenol, 4-[(2R,3S)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxy-, rel- Basic information |
| Product Name: | Phenol, 4-[(2R,3S)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxy-, rel- | | Synonyms: | Phenol, 4-[(2R,3S)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxy-, rel-;erythro-Austrobailignan-6 | | CAS: | 114127-24-1 | | MF: | C20H24O4 | | MW: | 328.4 | | EINECS: | | | Product Categories: | | | Mol File: | 114127-24-1.mol | ![Phenol, 4-[(2R,3S)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxy-, rel- Structure](CAS/20210111/GIF/114127-24-1.gif) |
| | Phenol, 4-[(2R,3S)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxy-, rel- Chemical Properties |
| Boiling point | 467.0±40.0 °C(Predicted) | | density | 1.159±0.06 g/cm3(Predicted) | | pka | 10.19±0.20(Predicted) |
| | Phenol, 4-[(2R,3S)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxy-, rel- Usage And Synthesis |
| Uses | erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK[1][2]. | | in vivo | erythro-Austrobailignan-6 (food intake, for 20 days) inhibits tumor growth in 4T-1 tumor bearing mice[1].
| Animal Model: | 4T-1 tumor bearing mice[1] | | Dosage: | 20 mg/kg/day | | Administration: | Food intake | | Result: | Inhibited tumor growth by 40.8%;
Down-regulated CDK-4, cyclin D1, HER2 and integrin β3;
Up-regulated cleaved caspase-3 in tumor.
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| | References | [1] Han JH, et al. Erythro-austrobailignan-6 down-regulates HER2/EGFR/integrinβ3 expression via p38 activation in breast cancer. Phytomedicine. 2017 Jan 15;24:24-30. DOI:10.1016/j.phymed.2016.11.009
[2] Lee YK, et al. Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis. Arch Pharm Res. 2009 Oct;32(10):1409-15. DOI:10.1007/s12272-009-2010-7 |
| | Phenol, 4-[(2R,3S)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxy-, rel- Preparation Products And Raw materials |
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