2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, (5S)-

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2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, (5S)- manufacturers
2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, (5S)- Basic information
Product Name:2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, (5S)-
Synonyms:2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, (5S)-;GSK2850163 (S enantiomer), 10 mM in DMSO
CAS:2309519-81-9
MF:C24H29Cl2N3O
MW:446.41
EINECS:
Product Categories:
Mol File:2309519-81-9.mol
2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, (5S)- Structure
2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, (5S)- Chemical Properties
Boiling point 625.6±55.0 °C(Predicted)
density 1.28±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka13.81±0.20(Predicted)
Safety Information
MSDS Information
2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, (5S)- Usage And Synthesis
UsesGSK2850163 S enantiomer is the inactive enantiomer of GSK2850163. GSK2850163 is an inositol-requiring enzyme-1 alpha (IRE1a) inhibitor.
References[1] Nestor O. Concha, et al. Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1αEndoribonuclease Activity. Molecular Pharmacology December 2015, 88 (6) 1011-1023.
2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, (5S)- Preparation Products And Raw materials
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