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| | 2-BROMO-4-METHOXY-PHENYLAMINE Basic information |
| Product Name: | 2-BROMO-4-METHOXY-PHENYLAMINE | | Synonyms: | 2-BROMO-4-METHOXY-PHENYLAMINE;2-Bromo-p-anisidine;2-N,4-N-diethyl-6-ethylsulfanyl-1,3,5-triazine-2,4-diamine;ethyl-[4-(ethylamino)-6-(ethylthio)-s-triazin-2-yl]amine;N2,N4-diethyl-6-ethylsulfanyl-1,3,5-triazine-2,4-diamine;2-Bromo-4-methoxyaniline 95%;4-Amino-3-bromoanisole, 2-Bromo-p-anisidine;4-AMino-3-broMoanisole[2-BroMo-4-Methoxyaniline] | | CAS: | 32338-02-6 | | MF: | C7H8BrNO | | MW: | 202.05 | | EINECS: | | | Product Categories: | Anilines, Aromatic Amines and Nitro Compounds | | Mol File: | 32338-02-6.mol |  |
| | 2-BROMO-4-METHOXY-PHENYLAMINE Chemical Properties |
| Melting point | 64 °C | | Boiling point | 76-98 °C(Press: 2 Torr) | | density | 1.531±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | Chloroform (Slightly), DMSO (Slightly) | | form | liquid | | pka | 3.14±0.10(Predicted) | | color | Clear, dark red |
| HazardClass | IRRITANT | | HS Code | 2922290090 |
| | 2-BROMO-4-METHOXY-PHENYLAMINE Usage And Synthesis |
| Uses | 2-Bromo-4-methoxyaniline is a useful reagent and reactant in organometallics, and organic reactions. | | Synthesis | General procedure for the synthesis of 2-bromo-4-methoxyaniline from 4-methoxyaniline: N-bromosuccinimide (NBS, 152 g, 853 mmol) was added batchwise to a tetrahydrofuran (THF, 3 L) solution of 4-methoxyaniline (100 g, 812 mmol) at -10 °C, keeping the temperature constant and stirring continuously for 30 min. After completion of the reaction, the mixture was concentrated under reduced pressure. The residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate, 15:1, v/v) to afford the target product 2-bromo-4-methoxyaniline as a red oil (30.58 g, 18.6% yield). The nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, CDCl3) data were as follows: δ = 7.01 (d, J = 2.4 Hz, 1H), 6.74-6.70 (m, 2H), 3.85-3.74 (m, 2H), 3.73 (s, 3H). | | References | [1] Russian Journal of Applied Chemistry, 2009, vol. 82, # 9, p. 1570 - 1576
[2] Journal of the Chilean Chemical Society, 2011, vol. 56, # 4, p. 863 - 865
[3] Organic Letters, 2006, vol. 8, # 19, p. 4291 - 4293
[4] Journal of the Brazilian Chemical Society, 2010, vol. 21, # 3, p. 496 - 501
[5] Synthetic Communications, 2010, vol. 40, # 6, p. 868 - 876 |
| | 2-BROMO-4-METHOXY-PHENYLAMINE Preparation Products And Raw materials |
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