- 2-Picolylamine
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- $1.10 / 1g
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2025-11-18
- CAS:3731-51-9
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons min
- 2-Picolylamine
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- $122.00 / 1KG
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2025-09-25
- CAS:3731-51-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- 2-Picolylamine
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- $0.00 / 200KG
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2025-06-27
- CAS:3731-51-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| | 2-Picolylamine Chemical Properties |
| Melting point | 20°C | | Boiling point | 82-85 °C12 mm Hg(lit.) | | density | 1.049 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.578(lit.) | | Fp | 194 °F | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | pka | pK1: 2.31(+2);pK2: 8.79(+1) (25°C,μ=0.5) | | form | Liquid | | color | Clear colorless to yellow or orange | | PH | 11-12 (100g/l, H2O, 20℃) | | Water Solubility | SOLUBLE | | Sensitive | Air Sensitive | | BRN | 108054 | | InChI | 1S/C6H8N2/c7-5-6-3-1-2-4-8-6/h1-4H,5,7H2 | | InChIKey | WOXFMYVTSLAQMO-UHFFFAOYSA-N | | SMILES | NCc1ccccn1 | | CAS DataBase Reference | 3731-51-9(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Pyridinemethanamine(3731-51-9) | | EPA Substance Registry System | 2-Pyridinemethanamine (3731-51-9) |
| Hazard Codes | C,Xi | | Risk Statements | 36/37/38-34-37 | | Safety Statements | 26-36/37/39-45-25-36-27 | | RIDADR | UN 2735 8/PG 2 | | WGK Germany | 3 | | RTECS | US1840000 | | Hazard Note | Corrosive | | TSCA | TSCA listed | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29333999 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Skin Corr. 1B |
| | 2-Picolylamine Usage And Synthesis |
| Description | It is usually used as the intermediate or raw material in the organic synthesis and pharmaceutical synthesis. For example, this chemical can promote the Al(OTf)3-catalyzed aminolysis of 1,2-epoxides to produce β-Amino alcohols N-2'-pyridylmethyl in excellent yields.1 Moreover, this substance may function as the raw material to produce copper(Ⅱ) complexes with sulfonamides that act as the active chemical nucleases.2 In addition, by using this chemical as substrate, an efficient [2+3] cycloaddition approach has been developed for the synthesis of pyridyl-appended fullerene ligands.3 Besides, 2-picolylamine is chosen as the recognition group to get better selectivity for a rhodamine-based “turn-on” fluorescent probe for Fe3+ in aqueous solution.4
| | Reference |
- Fringuelli, F.; Pizzo, F.; Tortoioli, S.; Vaccaro, L., Solvent-free Al(OTf)(3)-catalyzed aminolysis of 1,2-epoxides by 2-picolylamine: A key step in the synthesis of ionic liquids. J. Org. Chem. 2004, 69, 7745-7747.
- Macias, B.; Villa, M. V.; Salgado, M.; Borras, J.; Gonzalez-Alvarez, M.; Sanz, F., Copper(II) complexes with sulfonamides derived from 2-picolylamine and their use as chemical nucleases. Inorg. Chim. Acta 2006, 359, 1465-1472.
- Troshin, P. A.; Peregudov, A. S.; Muhlbacher, D.; Lyubovskaya, R. N., An efficient 2+3 cycloaddition approach to the synthesis of pyridyl-appended fullerene ligands. Eur. J. Org. Chem. 2005, 3064-3074.
- Ji, S. Z.; Meng, X. M.; Ye, W. P.; Feng, Y.; Sheng, H. T.; Cai, Y. L.; Liu, J. S.; Zhu, X. F.; Guo, Q. X., A rhodamine-based "turn-on" fluorescent probe for Fe3+ in aqueous solution. Dalton Trans. 2014, 43, 1583-1588.
| | Chemical Properties | clear colorless to yellow or orange liquid | | Uses | 2-Picolylamine is a bihaptic amine that can be used:
- As a key precursor to synthesize various ionic liquids through the formation of β-amino alcohols as intermediates.
- As a chelating ligand for the synthesis of complexes such as zinc picolylamine complex and Cu(II) picolylamine complex.
- To functionalize poly(styrene-co-maleic anhydride) (PSMA) resin to facilitate the adsorption of uranium from aqueous solution.
| | Uses | 2-Picolylamine may be used as a derivatization agent to enhance the sensitivity of carboxylic acids and short-chain fatty acids for their determination in biological samples by liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) and ultra-high performance liquid chromatography (UHPLC), respectively. | | Definition | ChEBI: 2-Pyridinemethanamine is a member of pyridines. | | General Description | 2-Picolylamine, a bihaptic nucleophile, is a bidentate ligand that is generally utilized for the preparation of various multidentate ligands and the corresponding complexes. | | Toxics Screening Level | The initial threshold screening level (ITSL) for 2-(aminomethyl)pyridine is 0.1μg/m3 (annual averaging time). |
| | 2-Picolylamine Preparation Products And Raw materials |
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