Imidazo[1,2-a]pyridine-6-carboxamide, N-cyclobutyl-2-[3-[[[[2-(1-piperidinyl)ethyl]amino]sulfonyl]amino]phenyl]-

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Imidazo[1,2-a]pyridine-6-carboxamide, N-cyclobutyl-2-[3-[[[[2-(1-piperidinyl)ethyl]amino]sulfonyl]amino]phenyl]- manufacturers

  • SR-0813
  • SR-0813 pictures
  • $35.00
  • 2026-07-17
  • CAS:2597186-19-9
  • Purity: 99.72%
  • Supply Ability: 10g
Imidazo[1,2-a]pyridine-6-carboxamide, N-cyclobutyl-2-[3-[[[[2-(1-piperidinyl)ethyl]amino]sulfonyl]amino]phenyl]- Basic information
Product Name:Imidazo[1,2-a]pyridine-6-carboxamide, N-cyclobutyl-2-[3-[[[[2-(1-piperidinyl)ethyl]amino]sulfonyl]amino]phenyl]-
Synonyms:Imidazo[1,2-a]pyridine-6-carboxamide, N-cyclobutyl-2-[3-[[[[2-(1-piperidinyl)ethyl]amino]sulfonyl]amino]phenyl]-;N-cyclobutyl-2-(3-((N-(2-(piperidin-1-yl)ethyl)sulfamoyl)amino)phenyl)imidazo[1,2-a]pyridine-6-carboxamide;SR0813,SR 0813;Compound SR-0813;SR-0813, 10 mM in DMSO;SR-0813 ，E1185
CAS:2597186-19-9
MF:C25H32N6O3S
MW:496.62
EINECS:
Product Categories:APIs
Mol File:2597186-19-9.mol
Imidazo[1,2-a]pyridine-6-carboxamide, N-cyclobutyl-2-[3-[[[[2-(1-piperidinyl)ethyl]amino]sulfonyl]amino]phenyl]- Structure
Imidazo[1,2-a]pyridine-6-carboxamide, N-cyclobutyl-2-[3-[[[[2-(1-piperidinyl)ethyl]amino]sulfonyl]amino]phenyl]- Chemical Properties
density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 93 mg/mL (187.26 mM);Ethanol: 5 mg/mL (10.07 mM)
pka6.96±0.50(Predicted)
form Solid
color White to off-white
Water Solubility Water: Insoluble
Safety Information
MSDS Information
Imidazo[1,2-a]pyridine-6-carboxamide, N-cyclobutyl-2-[3-[[[[2-(1-piperidinyl)ethyl]amino]sulfonyl]amino]phenyl]- Usage And Synthesis
UsesSR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 and EC50 values of 25 nM and 205 nM for ENL YEATS domain, respectively. SR-0813 has IC50 and EC50 values of 311 nM and 76 nM (CETSA) for AF9 YEATS domain, respectively. SR-0813 binds MAP3K19 with over 100-fold lower affinity (Kd=3.5 μM) than ENL YEATS (Kd=30 nM). SR-0813 can be used for the research of acute leukemia[1].
Biological ActivitySR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 values of 25 and 311 nM for ENL YEATS domain and AF9 YEATS domain, respectively.
IC 50ENL YEATS domain: 25 nM (IC50); ENL YEATS domain: 205 nM (EC50); AF9 YEATS domain: 311 nM (IC50); AF9 YEATS domain: 76 nM (EC50); ENL YEATS domain: 30 nM (Kd); MAP3K19: 3.5 μM (Kd)
References[1] Garnar-Wortzel L, et al. ACS Cent Sci. 2021 May 26;7(5):815-830.
Imidazo[1,2-a]pyridine-6-carboxamide, N-cyclobutyl-2-[3-[[[[2-(1-piperidinyl)ethyl]amino]sulfonyl]amino]phenyl]- Preparation Products And Raw materials
Tag:Imidazo[1,2-a]pyridine-6-carboxamide, N-cyclobutyl-2-[3-[[[[2-(1-piperidinyl)ethyl]amino]sulfonyl]amino]phenyl]-(2597186-19-9) Related Product Information
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