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Alfa Chemistry |
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Product Name:(3S,5S,10S,13R,14S,17R)-3,5,14-Trihydroxy-13-methyl-17-(6-oxopyran-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde
CAS:465-90-7
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Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3beta,5beta)- manufacturers
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| | Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3beta,5beta)- Basic information |
| Product Name: | Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3beta,5beta)- | | Synonyms: | Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3beta,5beta)-;Hellebrigenin;19-Oxo-3β,5,14-trihydroxy-5β-bufa-20,22-dienolide;3β,5,14-Trihydroxy-19-oxo-5β-bufa-20,22-dienolide;(3S,5S,10S,13R,14S,17R)-3,5,14-Trihydroxy-13-methyl-17-(6-oxopyran-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde;Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3β,5β)- | | CAS: | 465-90-7 | | MF: | C24H32O6 | | MW: | 416.50728 | | EINECS: | 207-368-3 | | Product Categories: | | | Mol File: | 465-90-7.mol |  |
| | Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3beta,5beta)- Chemical Properties |
| Melting point | 175 °C(Solv: ethanol (64-17-5)) | | Boiling point | 626.3±55.0 °C(Predicted) | | density | 1.419±0.06 g/cm3(Predicted) | | storage temp. | 4°C, away from moisture and light | | pka | 13.94±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3beta,5beta)- Usage And Synthesis |
| Uses | Hellebrigenin, one of bufadienolides belonging to cardioactive steroids, is isolated from traditional Chinese medicine Venenum Bufonis. Hellebrigenin induces DNA damage and cell cycle G2/M arrest. Hellebrigenin triggers mitochondria-mediated apoptosis. | | References | [1] Deng LJ, et al. Hellebrigenin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Chem Biol Interact. 2014 Aug 5;219:184-94. DOI:10.1016/j.cbi.2014.06.003 |
| | Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3beta,5beta)- Preparation Products And Raw materials |
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