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| | 3-Thiophenesulfonamide, N-(4-bromo-2-fluorophenyl)-2-methyl-5-(2-methyl-4-thiazolyl)- Basic information |
| | 3-Thiophenesulfonamide, N-(4-bromo-2-fluorophenyl)-2-methyl-5-(2-methyl-4-thiazolyl)- Chemical Properties |
| Boiling point | 553.2±60.0 °C(Predicted) | | density | 1.663±0.06 g/cm3(Predicted) | | pka | 7.47±0.50(Predicted) |
| | 3-Thiophenesulfonamide, N-(4-bromo-2-fluorophenyl)-2-methyl-5-(2-methyl-4-thiazolyl)- Usage And Synthesis |
| Uses | M351-0056 is the agonist for the immune checkpoint protein VISTA, that reduces the secretion of VISTA-induced cytokines, promotes the T-cell proliferation induced by VISTA, and exhibits immunomodulatory activity. M351-0056 ameliorates Imiquimod (HY-B0180)-induced psoriatic dermatitis in mouse models[1]. | | References | [1] Hu X, et al., M351-0056 is a novel low MW compound modulating the actions of the immune-checkpoint protein VISTA. Br J Pharmacol. 2021 Mar;178(6):1445-1458. DOI:10.1111/bph.15357 |
| | 3-Thiophenesulfonamide, N-(4-bromo-2-fluorophenyl)-2-methyl-5-(2-methyl-4-thiazolyl)- Preparation Products And Raw materials |
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