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| | 2-(4-fluorophenyl)propionic acid Basic information |
| Product Name: | 2-(4-fluorophenyl)propionic acid | | Synonyms: | 2-(4-fluorophenyl)propionic acid;4-Fluoro-alpha-methylphenylaceticacid;2-(4-Fluorophenyl)propanoic acid;4-Fluoro-α-methylbenzeneacetic acid;4-Fluoro-alpha-methylphenylacetic acid,98%;(+/-)-2-(4-flurophenyl)propanoic acid;Benzeneacetic acid, 4-fluoro-α-methyl-;Benzeneacetic acid,4-fluoro-a-methyl- | | CAS: | 75908-73-5 | | MF: | C9H9FO2 | | MW: | 168.16 | | EINECS: | 278-340-6 | | Product Categories: | | | Mol File: | 75908-73-5.mol |  |
| | 2-(4-fluorophenyl)propionic acid Chemical Properties |
| Boiling point | 258.8±15.0 °C(Predicted) | | density | 1+-.0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | solid | | pka | 4.31±0.10(Predicted) | | color | Off-white |
| RIDADR | 2811 | | HazardClass | 6.1 | | PackingGroup | Ⅲ | | HS Code | 2918199890 |
| | 2-(4-fluorophenyl)propionic acid Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2-(4-fluorophenyl)propionic acid from the compound (CAS: 50415-71-9) was as follows: under stirring conditions, racemic methyl 2-(4-thieno-phenyl)propionate (18.9 g) was dissolved in ethanol (200 mL) and an aqueous solution of potassium hydroxide (35 g) (200 mL) was slowly added. The reaction mixture was stirred continuously at 0 °C for 4 hours. Upon completion of the reaction, the pH was adjusted to 5 with 4.0 M hydrochloric acid, followed by extraction of the reaction mixture with ethyl acetate. The organic phase was separated and the solvent was removed by distillation under reduced pressure to give 15.64 g of 2-(4-fluorophenyl)propionic acid as a crude product. The crude product could be used directly in the subsequent reaction without further purification. The structure of the product was confirmed by 1H-NMR (300 MHz, DMSO-d6): δ [ppm] = 1.31 (d, 3H), 3.66 (q, 1H), 7.05-7.15 (m, 2H), 7.24-7.33 (m, 2H), 12.30 (s, 1H). | | References | [1] Organic letters, 2002, vol. 4, # 3, p. 371 - 373
[2] Journal of Organic Chemistry, 2003, vol. 68, # 19, p. 7234 - 7242
[3] Patent: WO2010/31183, 2010, A1. Location in patent: Page/Page column 18
[4] Patent: WO2013/87579, 2013, A1. Location in patent: Page/Page column 134; 135
[5] Patent: WO2014/9219, 2014, A1. Location in patent: Page/Page column 107; 108 |
| | 2-(4-fluorophenyl)propionic acid Preparation Products And Raw materials |
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