methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride

methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride Suppliers list

Company Name:	Chemsky（shanghai）International Co.,Ltd.
Tel:	021-50135380
Email:	shchemsky@sina.com

Company Name:	Finetech Industry Limited
Tel:	027-87465837 19945049750
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methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride manufacturers

methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride Basic information

Product Name:	methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride
Synonyms:	methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride;PITOFENONEHYDROCHLORIDE(FORR&DONLY);2-[4-(2-piperidinoethoxy)benzoyl]benzoic acid methyl ester hydrochloride;methyl 2-[4-(2-piperidin-1-ylethoxy)benzoyl]benzoate hydrochloride;methyl 2-[4-(2-piperidin-1-ylethoxy)phenyl]carbonylbenzoate hydrochloride;Pitophenone hydrochloride;Baralgin Ketone Hydrochloride;Benzoic acid,2-[4-[2-(1-piperidinyl)ethoxy]benzoyl]-, methyl ester, hydrochloride (1:1)
CAS:	1248-42-6
MF:	C22H26ClNO4
MW:	403.89914
EINECS:	214-999-8
Product Categories:	Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	1248-42-6.mol

methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride Chemical Properties

Melting point	169-170°C
storage temp.	Inert atmosphere,Room Temperature
solubility	DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:5): 0.16 mg/ml
form	A crystalline solid
color	White to off-white
Water Solubility	H2O: 2mg/mL, clear
InChI	1S/C22H25NO4.ClH/c1-26-22(25)20-8-4-3-7-19(20)21(24)17-9-11-18(12-10-17)27-16-15-23-13-5-2-6-14-23;/h3-4,7-12H,2,5-6,13-16H2,1H3;1H
InChIKey	ZRFIFDFEDPJBII-UHFFFAOYSA-N
SMILES	[Cl-].N3(CCCCC3)CCOc1ccc(cc1)C(=O)c2c(cccc2)C(=O)OC.[H+]

Safety Information

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

MSDS Information

methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride Usage And Synthesis

Description	Pitofenone is an antispasmodic agent and an inhibitor of acetylcholinesterase (AChE; K_is = 36 and 45 μM for bovine erythrocyte and electric eel enzyme, respectively). It inhibits acetylcholine-induced contractions of isolated guinea pig ileum when used at a concentration of 2.5 μM.
Chemical Properties	White Solid
Uses	Diclofenac and its combination with Pitofenone and Fenpiverinium shows antispasmodic activity.
IC 50	AChE
References	[1] N S PUNEKAR A V K. Acetylcholinesterase inhibition by pitofenone: a spasmolytic compound.[J]. Biotechnology and applied biochemistry, 1991, 14 3: 378-382. [2] SHRINIVAS K KULKARNI. Modulatory effect of diclofenac on antispasmodic effect of pitofenone in cholinergic spasm.[J]. Indian journal of experimental biology, 2004, 42 6: 567-569.

methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride Preparation Products And Raw materials

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