| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:TLR8 agonist 2
CAS:2412937-64-3
Package:25mg/RMB 10600
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| Company Name: |
Biorbyt Ltd.
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| Tel: |
+44 (0)1223 859 353 |
| Email: |
info@biorbyt.com |
| Products Intro: |
Product Name:TLR8 agonist 2
CAS:2412937-64-3
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| | Pyrido[3,4-d]pyrimidine-2,4-diamine, N4-[(1R)-1-methyl-1-(1H-1,2,4-triazol-5-ylmethyl)pentyl]- Basic information |
| Product Name: | Pyrido[3,4-d]pyrimidine-2,4-diamine, N4-[(1R)-1-methyl-1-(1H-1,2,4-triazol-5-ylmethyl)pentyl]- | | Synonyms: | Pyrido[3,4-d]pyrimidine-2,4-diamine, N4-[(1R)-1-methyl-1-(1H-1,2,4-triazol-5-ylmethyl)pentyl]-;TLR8 agonist 2 | | CAS: | 2412937-64-3 | | MF: | C16H22N8 | | MW: | 326.4 | | EINECS: | | | Product Categories: | | | Mol File: | 2412937-64-3.mol | ![Pyrido[3,4-d]pyrimidine-2,4-diamine, N4-[(1R)-1-methyl-1-(1H-1,2,4-triazol-5-ylmethyl)pentyl]- Structure](CAS/20210305/GIF/2412937-64-3.gif) |
| | Pyrido[3,4-d]pyrimidine-2,4-diamine, N4-[(1R)-1-methyl-1-(1H-1,2,4-triazol-5-ylmethyl)pentyl]- Chemical Properties |
| Boiling point | 656.5±65.0 °C(Predicted) | | density | 1.308±0.06 g/cm3(Predicted) | | pka | 10.60±0.20(Predicted) |
| | Pyrido[3,4-d]pyrimidine-2,4-diamine, N4-[(1R)-1-methyl-1-(1H-1,2,4-triazol-5-ylmethyl)pentyl]- Usage And Synthesis |
| Uses | TLR8 agonist 2 is a potent and selective TLR8 agonist with an EC50 of 3 nM for human TLR8. TLR8 agonist 2 shows less active against human TLR7 (EC50 of 33.33 μM)[1]. | | in vivo | The pharmacokinetic related parameters of TLR8 agonist 2 (Example 1) in mice administered with the intravenous administration of 1 mg/kg and the oral administration of 5 mg/kg are detected. The T1/2 of TLR8 agonist 2 are 0.25 h (1 mg/kg i.v.) and 0.5 h (5 mg/kg p.o.), the AUClast are 450 ng/mL*hr (i.v.) and 624 ng/mL*hr (p.o.). And for oral administration, the bioavailability (%F) is 27.7%[1] | | IC 50 | TLR8: 3 nM (EC50); TLR7: 33.33 μM (EC50) | | References | [1] Zhe Cai, et al. Tlr8 agonist. WO2020057604A1. |
| | Pyrido[3,4-d]pyrimidine-2,4-diamine, N4-[(1R)-1-methyl-1-(1H-1,2,4-triazol-5-ylmethyl)pentyl]- Preparation Products And Raw materials |
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