| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
BSH-IN-1 manufacturers
- BSH-IN-1
-
- $118.00
-
2026-08-14
- CAS:2553217-91-5
- Purity: 99.89%
- Supply Ability: 10g
- BSH-IN-1
-
- $118.00
-
2026-08-14
- CAS:2553217-91-5
- Purity: 99.89%
- Supply Ability: 10g
|
| | BSH-IN-1 Basic information |
| Product Name: | BSH-IN-1 | | Synonyms: | BSH-IN-1;BSH IN 1,BSHIN1;26,27-Dinorcholestan-24-one, 25-fluoro-3,7-dihydroxy-, (3α,5β,7α)-;BSH-IN-1, 10 mM in DMSO | | CAS: | 2553217-91-5 | | MF: | C25H41FO3 | | MW: | 408.59 | | EINECS: | | | Product Categories: | | | Mol File: | 2553217-91-5.mol |  |
| | BSH-IN-1 Chemical Properties |
| Boiling point | 523.9±30.0 °C(Predicted) | | density | 1.097±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 10 mM | | form | A solid | | pka | 14.79±0.70(Predicted) | | color | White to yellow |
| | BSH-IN-1 Usage And Synthesis |
| Uses | BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively[1]. | | in vivo | BSH-IN-1 (Compound 7; 10mg/kg; a single dose; gavage) inhibits BSH activity in C57BL/6 mice and can be gut-restricted[1]. | Animal Model: | C57BL/6 mice[1] | | Dosage: | 10mg/kg | | Administration: | Single gavage | | Result: | Inhibited gut bacterial BSH activity and modulated the bile acid pool in vivo while not significantly affected the gut bacterial community. |
| | References | [1] Adhikari AA, et al. Development of a covalent inhibitor of gut bacterial bile salt hydrolases.Nat Chem Biol.2020 Mar;16(3):318-326. DOI:10.1038/s41589-020-0467-3 |
| | BSH-IN-1 Preparation Products And Raw materials |
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