- Guluronic acid
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2025-04-04
- CAS:15769-56-9
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
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| | guluronic acid Basic information |
| | guluronic acid Chemical Properties |
| Boiling point | 553.434±50.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.748±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 3.65 | | form | Solid | | color | White to off-white | | InChI | InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/t2-,3-,4+,5-/m0/s1 | | InChIKey | IAJILQKETJEXLJ-KLVWXMOXSA-N | | SMILES | O=C[C@@H]([C@@H]([C@H]([C@@H](C(O)=O)O)O)O)O |
| | guluronic acid Usage And Synthesis |
| Description | Glucuronic acid is a sugar acid derived from glucose, with its sixth carbon atom oxidized to a carboxylic acid. In living beings, this primary oxidation occurs with UDP-α-D-glucose (UDPG), not with the free sugar.
Glucuronic acid, like its precursor glucose, can exist as a linear (carboxo-)aldohexose (<1%), or as a cyclic hemiacetal (furanose or pyranose). Aldohexoses such as D-glucose are capable of forming two furanose forms (α and β) and two pyranose forms (α and β). By the Fischer convention, glucuronic acid has two stereoisomers (enantiomers), D- and L-glucuronic acid, depending on its configuration at C-5. Most physiological sugars are of the D-configuration. Due to ring closure, cyclic sugars have another asymmetric carbon atom (C-1), resulting in two more stereoisomers, named anomers. Depending on the configuration at C-1, there are two anomers of glucuronic acid, α- and β-form. In β-D-glucuronic acid the C-1 hydroxy group is on the same side of the pyranose ring as the carboxyl group. In the free sugar acid, the β-form is prevalent (~64%), whereas in the organism, the α-form UDP-α-D-glucuronic acid (UDPGA) predominates. | | Uses | Guluronic acid (G2013), one of the organic building blocks of hyaluronic acid, is a nonsteroidal anti-inflammatory agent has favorable anti-inflammatory effect[1][2]. | | References | [1] Amaniampong PN, et al. Selective and Catalyst-free Oxidation of D-Glucose to D-Glucuronic acid induced by High-Frequency Ultrasound. Sci Rep. 2017;7:40650. Published 2017 Jan 13. DOI:10.1038/srep40650
[2] Nazeri S, et al. The safety and efficacy of Guluronic acid (G2013) in ankylosing spondylitis: A randomized controlled parallel clinical trial. Pharmacol Rep. 2019;71(3):393-398. DOI:10.1016/j.pharep.2019.02.002 |
| | guluronic acid Preparation Products And Raw materials |
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