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| | Ethyl 5-bromothiophene-2-carboxylate Basic information |
| Product Name: | Ethyl 5-bromothiophene-2-carboxylate | | Synonyms: | Ethyl 5-bromo-2-thiophenecarboxylate;Ethyl 5-bromothiophene-2-carboxylate ,98.5%;5-Bromothiophene-2-carboxylic acid ethyl ester;Ethyl 5-bromothiophene-2-carboxylate;Ethyl 5-broMothiophene-2-carboxylateEthyl 5-broMothiophene-2-carboxylate;2-Thiophenecarboxylic acid, 5-broMo-, ethyl ester;5- broMothiophene -2-ethyl forMate;Ethyl5-bromothiophene-2-carboxylate,99% | | CAS: | 5751-83-7 | | MF: | C7H7BrO2S | | MW: | 235.1 | | EINECS: | | | Product Categories: | | | Mol File: | 5751-83-7.mol |  |
| | Ethyl 5-bromothiophene-2-carboxylate Chemical Properties |
| Boiling point | 94-96°C/4mm | | density | 1.572±0.06 g/cm3(Predicted) | | refractive index | 1.5600 to 1.5640 | | Fp | 94-96°C/4mm | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | clear liquid | | color | Light orange to Yellow to Green | | Water Solubility | Slightly soluble in water | | λmax | 277nm(Hexane)(lit.) | | InChI | InChI=1S/C7H7BrO2S/c1-2-10-7(9)5-3-4-6(8)11-5/h3-4H,2H2,1H3 | | InChIKey | PZNHMXAOMDQLLE-UHFFFAOYSA-N | | SMILES | C1(C(OCC)=O)SC(Br)=CC=1 |
| | Ethyl 5-bromothiophene-2-carboxylate Usage And Synthesis |
| Chemical Properties | Colourless to light yellow liquid | | Uses | Ethyl 5-bromothiophene-2-carboxylate is used as an intermediate in organic syntheses | | Synthesis | GENERAL STEPS: To a solution of commercially available 5-bromothiophene-2-carboxylic acid (10 g, 0.048 mol) and cesium carbonate (31.6 g, 0.096 mol) in N,N-dimethylformamide (100 mL) was slowly added ethyl iodide (11.3 g, 0.072 mol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate. The organic layer was washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography to afford pure ethyl 5-bromothiophene-2-carboxylate (9 g, 80% yield) as a light yellow oil.ESI-MS m/z: 234.1 [M + H]+ (calculated value: C7H7BrO2S).1H NMR (CDCl3, 400 MHz): δ 7.54-7.53 (d, J = 4 Hz, 1H, Harom), 7.07-7.53 (d, J = 4 Hz, 1H, Harom). Harom), 7.07-7.06 (d, J = 4 Hz, 1H, Harom), 4.35-4.30 (m, 2H, O-CH2-CH3), 1.38-1.34 (m, 3H, O-CH2-CH3). | | References | [1] European Journal of Medicinal Chemistry, 2018, vol. 150, p. 506 - 524 |
| | Ethyl 5-bromothiophene-2-carboxylate Preparation Products And Raw materials |
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