- 5-Nitro-1-tetralone
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2022-01-04
- CAS:51114-73-9
- Min. Order: 1g
- Purity: 98%minHPLC
- Supply Ability: 100kgs/month
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| | 5-Nitro-1-tetralone Basic information |
| Product Name: | 5-Nitro-1-tetralone | | Synonyms: | 5-Nitro-1-tetralone;5-Nitro-α-tetralone;5-NITRO-A-TETRALONE;3,4-dihydro-5-nitronaphthalen-1(2H)-one;5-nitro-3,4-dihydronaphthalen-1(2H)-one;5-nitro-1,2,3,4-tetrahydronaphthalen-1-one;5-Nitro-3,4-dihydro-2H-naphthalen-1-one;5-Nitro-3,4-dihydronaphthalen-1(2H) | | CAS: | 51114-73-9 | | MF: | C10H9NO3 | | MW: | 191.18 | | EINECS: | | | Product Categories: | | | Mol File: | 51114-73-9.mol |  |
| | 5-Nitro-1-tetralone Chemical Properties |
| Melting point | 103-104 °C | | Boiling point | 349.9±31.0 °C(Predicted) | | density | 1.322±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | Appearance | White to light yellow Solid |
| | 5-Nitro-1-tetralone Usage And Synthesis |
| Synthesis Reference(s) | Journal of Medicinal Chemistry, 19, p. 472, 1976 DOI: 10.1021/jm00226a004 | | Synthesis | The general procedure for the synthesis of 5-nitro-α-tetralone from 4-(2-nitrophenyl)butyric acid was as follows: first, 1 g of 4-(2-nitrophenyl)butyric acid (NPBS, 4.78 mmol) and 18 g of trifluoromethanesulfonic acid (TFMS) were added to a 100 mL two-necked flask fitted with a reflux condenser and magnetic stirrer at 20 °C. Under stirring, the reaction mixture was placed in an oil bath preheated to 130 °C and stirred continuously at this temperature for 45 min. Upon completion of the reaction, the mixture was cooled and transferred to a microdistillation unit. Most of the excess TFMS was removed by distillation at 52 °C and 0.5 mbar.After distillation, the bottom residue contained 0.914 g of 5-nitro-3,4-dihydro-1(2H)-naphthalenone and 3.44 g of TFMS (as determined by the GC-ISTD/internal standard method) in 99.3% yield, with 100% conversion to NPBS and 99.3% selectivity. | | References | [1] Patent: EP1369412, 2003, A1. Location in patent: Page 6
[2] Patent: US2003/176722, 2003, A1 |
| | 5-Nitro-1-tetralone Preparation Products And Raw materials |
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