- 4-Fluoroisoquinoline
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- $1.00 / 1kg
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2026-03-27
- CAS:394-67-2
- Min. Order: 1kg
- Purity: 98
- Supply Ability: 100
- 4-Fluoroisoquinoline
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- $0.00 / 25kg
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2025-12-01
- CAS:394-67-2
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
- 4-Fluoroisoquinoline
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- $1.10 / 1g
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2025-11-18
- CAS:394-67-2
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons
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| | 4-Fluoroisoquinoline Basic information |
| Product Name: | 4-Fluoroisoquinoline | | Synonyms: | 4-fluoroisoquinoline sulfate;Isoquinoline, 4-fluoro-;4-Fluoroisoquinoline 95+%;4-Fluoroisoquinoline ISO 9001：2015 REACH;4-FLUOROISOQUINOLINE;4-Floro isoquinoli11e | | CAS: | 394-67-2 | | MF: | C9H6FN | | MW: | 147.15 | | EINECS: | | | Product Categories: | | | Mol File: | 394-67-2.mol |  |
| | 4-Fluoroisoquinoline Chemical Properties |
| Melting point | 34 °C | | Boiling point | 240℃ | | density | 1.216 | | refractive index | 1.5914 | | Fp | 99℃ | | storage temp. | 2-8°C | | pka | 3.45±0.10(Predicted) | | form | powder to lump | | color | White to Light yellow | | InChI | InChI=1S/C9H6FN/c10-9-6-11-5-7-3-1-2-4-8(7)9/h1-6H | | InChIKey | VFFQGPWQVYUFLV-UHFFFAOYSA-N | | SMILES | C1C2=C(C=CC=C2)C(F)=CN=1 |
| | 4-Fluoroisoquinoline Usage And Synthesis |
| Uses | 4-fluoroisoquinoline is a useful research chemical. | | Synthesis | General procedure for the synthesis of 4-fluoroisoquinoline from 4-bromoisoquinoline: A solution of 4-bromoisoquinoline (20 g, 96.6 mmol) dissolved in 144 mL of THF was added slowly and dropwise to a 760 mL THF solution containing n-butyllithium (133 mL, 332.5 mmol, 2.5 M in THF) at -65 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at -65 °C for 30 min. Subsequently, a solution of N-fluorobenzenesulfonimide (66.68 g, 211.7 mmol) dissolved in 216 mL THF was added dropwise at the same temperature. After addition, the reaction was maintained at -65 °C for 1 hour. Upon completion of the reaction, the mixture was slowly warmed to room temperature and the reaction was quenched by the addition of 300 mL of saturated aqueous ammonium chloride. The reaction mixture was extracted with ethyl acetate (300 mL x 3), and the combined organic phases were washed with 300 mL of saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (elution gradient: 0-100% ethyl acetate/petroleum ether) to afford 4-fluoroisoquinoline (8.5 g, red oil, yield: 60%). | | References | [1] Journal of the American Chemical Society, 2014, vol. 136, # 10, p. 3792 - 3795
[2] Patent: US2017/37050, 2017, A1. Location in patent: Paragraph 0301; 0302
[3] Patent: US2007/179127, 2007, A1. Location in patent: Page/Page column 47-48
[4] Patent: US2009/48223, 2009, A1. Location in patent: Page/Page column 101
[5] Patent: US2010/93789, 2010, A1. Location in patent: Page/Page column 46 |
| | 4-Fluoroisoquinoline Preparation Products And Raw materials |
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