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Sigma-Aldrich |
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MELOXICAM SODIUM SALT HYDRATE manufacturers
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| | MELOXICAM SODIUM SALT HYDRATE Basic information |
| Product Name: | MELOXICAM SODIUM SALT HYDRATE | | Synonyms: | MELOXICAM SODIUM SALT HYDRATE;4-hydroxy-2-methyl-n-(5-methyl-2-thiazolyl)-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide sodium hydrate;Meloxicam hydrate sodium salt;Metacam hydrate sodium salt, Mobec hydrate sodium salt, UH-AC 62XX hydrate sodium salt, 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide hydrate sodium;Mobec sodium salt hydrate;UH-AC 62XX sodium salt hydrate;Meloxicam sodium salt;FRMZBLMVNUXMTO-UHFFFAOYSA-N | | CAS: | 71125-39-8 | | MF: | C14H12N3NaO4S2 | | MW: | 374.39 | | EINECS: | | | Product Categories: | | | Mol File: | 71125-39-8.mol |  |
| | MELOXICAM SODIUM SALT HYDRATE Chemical Properties |
| storage temp. | room temp | | solubility | DMSO: soluble5mg/mL, clear | | form | powder | | color | light yellow to dark yellow | | InChI | 1S/C14H13N3O4S2.Na.H2O/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2;;/h3-7,18H,1-2H3,(H,15,16,19);;1H2/q;+1;/p-1 | | InChIKey | IZBZAOZGNNQKPJ-UHFFFAOYSA-M | | SMILES | O.[Na+].CN1C(C(=O)Nc2ncc(C)s2)=C([O-])c3ccccc3S1(=O)=O |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | MELOXICAM SODIUM SALT HYDRATE Usage And Synthesis |
| Uses | Meloxicam sodium salt hydrate has been used:
- as a cyclooxygenase-2 (COX-2) inhibitor in solid Ehrlich tumor
- as an alternative to diclofenac nonsteroidal anti-inflammatory drugs (NSAID) to treat vultures
- as a reference standard in liquid chromatography electrospray ionisation mass spectrometry (LC-ESI/MS)
- to test its effect on prostaglandin (PGE2) production in lipopolysaccharide (LPS)-induced COX-2 protein expression in RAW246.7 cells
| | Biochem/physiol Actions | Meloxicam, a member of the oxicam family, is a non-steroidal anti-inflammatory drug (NSAID). It is synthesized from piroxicam with aryl and the pyridyl ring substitution. Meloxicam is a cyclooxygenase-2 (COX-2) inhibitor, it may be useful in treating inflammation and pain. Meloxicam has been shown to stop thymulin-induced increas in concentration of cytokines and Nerve growth factor(NGF) in the liver of rats. Meloxicam also suppresses tumor growth and may be capable of antagonizing cachexiain vitro. It promotes apoptosis in hepatocellular carcinoma. |
| | MELOXICAM SODIUM SALT HYDRATE Preparation Products And Raw materials |
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