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| | 9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester Basic information |
| | 9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester Chemical Properties |
| Boiling point | 854.2±65.0 °C(Predicted) | | density | 0.915±0.06 g/cm3(Predicted) | | solubility | DMSO: soluble | | form | Viscous Liquid | | pka | 15.21±0.29(Predicted) | | color | Colorless to light yellow |
| | 9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester Usage And Synthesis |
| Description | CL4H6 is an ionizable cationic amino lipid (apparent pKa = 6.35) that has been used in the generation of lipid nanoparticles (LNPs).1 LNPs containing CL4H6 and encapsulating Factor VII-targeting siRNA decrease hepatic levels of Factor VII in mice. Intravenous administration of LNPs containing CL4H6 and encapsulating siRNA targeting CD45 accumulate in tumor-associated macrophages and encapsulating siRNAs targeting STAT3 and HIF-1α decrease tumor volume in OS-RC-2 renal cancer mouse xenograft models.2 | | Uses | CL4H6 is a pH-sensitive cationic lipid. CL4H6 is the main component of lipid nanoparticles (LNPs), which can be used to target and deliver siRNA, and induces a potent gene-silencing response[1][2]. | | in vivo | The optimized siRNA-loaded CL4H6-LNPs are selectively and efficiently taken up and showed strong gene silencing activity in tumor-associated macrophages (TAMs) in a human tumor xenograft model in nude mice. The anti-tumor therapeutic response is obtained through the silencing of the STAT3 and HIF-1α, which resulted in an increase in the level of infiltrated macrophage (CD11b+ cells) into the tumor-microenvironment (TME) as well as a tendency to increase the concentration of M1 macrophages (CD169+ cells). The treatment also resulted in reversing the pro-tumorous functions of TAMs -mainly angiogenesis and tumor cell activation-, as evidenced by a decrease in the related gene expression at the mRNA level[1]. | | References | 1. Sato, Y., Hashiba, K., Sasaki, K., et al. Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo J. Control. Release 295,140-152(2019).
2. Shobaki, N., Sato, Y., Suzuki, Y., et al. Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy J. Control. Release 325,235-248(2020). |
| | 9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester Preparation Products And Raw materials |
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