| Company Name: |
Chengdu Youngshe Chemical Co., Ltd.
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| Tel: |
+86-17380623303 +86-17380623303; |
| Email: |
Caroline@youngshechem.com |
| Products Intro: |
Product Name:P8RI
CAS:2147724-76-1
Purity:95% Package:1G; 10G; 100G
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| Company Name: |
Hangzhou Peptidego Biotech Co.,Ltd.
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| Tel: |
0571-87213919 |
| Email: |
Eric@peptidego.com |
| Products Intro: |
CAS:2147724-76-1
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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| Company Name: |
Hangzhou Go Top Peptide Biotech
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| Tel: |
15397062932 |
| Email: |
sales1@gotopbio.com |
| Products Intro: |
Product Name:P8RI
CAS:2147724-76-1
Purity:98% Package:1mg/RMB 90;100mg10000mg
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| | D-Arginine, D-lysyl-D-tryptophyl-D-prolyl-D-alanyl-D-leucyl-D-phenylalanyl-D-valyl- Basic information |
| | D-Arginine, D-lysyl-D-tryptophyl-D-prolyl-D-alanyl-D-leucyl-D-phenylalanyl-D-valyl- Chemical Properties |
| density | 1.36±0.1 g/cm3(Predicted) | | pka | 3.32±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | D-Arginine, D-lysyl-D-tryptophyl-D-prolyl-D-alanyl-D-leucyl-D-phenylalanyl-D-valyl- Usage And Synthesis |
| Uses | P8RI (D-P8RI) is a biomimetic peptide of CD31 and a CD31 agonist. P8RI binds to the juxtamembrane amino acid sequence of the ectodomain of CD31, shows an immunosuppressive effect through restoration of the CD31 inhibitory pathway[1][2]. | | in vivo | P8RI (2.5 mg/kg; s.c.; daily from 7 to 28 after the occurrence of ADIM) prevents aneurysmal transformation by promoting the resolution of intramural hematoma and the production of collagen in dissected aortas in vivo, associated with enrichment of M2 macrophages at the site of injury[3]. | Animal Model: | Apo E -/- mice (male, 28-week-old) implanted with Ang II-releasing pumps (a model of experimental acute aortic dissection and intramural hematoma (ADIM))[3] | | Dosage: | 2.5 mg/kg | | Administration: | Subcutaneous injection; daily from 7 to 28 (after the implantation of the osmotic pump delivering Ang II) | | Result: | Aneurysmal transformation was significantly reduced.
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| | References | [1] Diaz-Rodriguez S, et al. Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo. Eur Heart J. 2021;42(18):1760-1769. DOI:10.1093/eurheartj/ehab027
[2] Sannier A, et al. A CD31-Derived Peptide Prevents the Development of Antibody-Mediated Lesions in a Rat Model of Aortic Allograft. Transplant Proc. 2021;53(2):746-749. DOI:10.1016/j.transproceed.2021.01.003
[3] Andreata F, et al. Macrophage CD31 Signaling in Dissecting Aortic Aneurysm. J Am Coll Cardiol. 2018;72(1):45-57. DOI:10.1016/j.jacc.2018.04.047 |
| | D-Arginine, D-lysyl-D-tryptophyl-D-prolyl-D-alanyl-D-leucyl-D-phenylalanyl-D-valyl- Preparation Products And Raw materials |
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