1H-Pyrazole-3-carboxamide, 5-[1-[(4-fluorophenyl)methyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]-N-(3-pyridinylmethyl)-

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1H-Pyrazole-3-carboxamide, 5-[1-[(4-fluorophenyl)methyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]-N-(3-pyridinylmethyl)- manufacturers

  • SCD1 inhibitor-3
  • SCD1 inhibitor-3 pictures
  • $84.00
  • 2026-07-17
  • CAS:1282606-48-7
  • Purity: 99.50%
  • Supply Ability: 10g
1H-Pyrazole-3-carboxamide, 5-[1-[(4-fluorophenyl)methyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]-N-(3-pyridinylmethyl)- Basic information
Product Name:1H-Pyrazole-3-carboxamide, 5-[1-[(4-fluorophenyl)methyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]-N-(3-pyridinylmethyl)-
Synonyms:1H-Pyrazole-3-carboxamide, 5-[1-[(4-fluorophenyl)methyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]-N-(3-pyridinylmethyl)-;SCD1 inhibitor-3;FUN06487;5-{1-[(4-fluorophenyl)methyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-4-yl}-N-[(pyridin-3-yl)methyl]-1H-pyrazole-3-carboxamide;SCD1 inhibitor-3, 10 mM in DMSO
CAS:1282606-48-7
MF:C19H16FN7O2
MW:393.37
EINECS:
Product Categories:
Mol File:1282606-48-7.mol
1H-Pyrazole-3-carboxamide, 5-[1-[(4-fluorophenyl)methyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]-N-(3-pyridinylmethyl)- Structure
1H-Pyrazole-3-carboxamide, 5-[1-[(4-fluorophenyl)methyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]-N-(3-pyridinylmethyl)- Chemical Properties
density 1.47±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 125 mg/mL (317.77 mM)
pka11.56±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
1H-Pyrazole-3-carboxamide, 5-[1-[(4-fluorophenyl)methyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]-N-(3-pyridinylmethyl)- Usage And Synthesis
DescriptionFUN06487, also known as SCD1 inhibitor-3, is a SCD1 inhibitor. This compound was first reported in WO 2011039358. This product has no formal name at the moment.
UsesSCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer[1].
in vivo

SCD1 inhibitor-3 (compound 17a) (5 mg/kg; p.o.; 4 hours) reduces the plasma C16:1/C16:0 triglycerides desaturation index by 54 %[1].
SCD1 inhibitor-3 (2~10 mg/kg; p.o.; 4 hours) makes a dose-responsive reduction of plasma triglycerides desaturation index[1].

Animal Model:Lewis rats[1]
Dosage:5 mg/kg
Administration:P.o.; 4 hours
Result:Reduced the plasma C16:1/C16:0 triglycerides desaturation index by 54 %.
Animal Model:Lewis rats[1]
Dosage:2~10 mg/kg
Administration:P.o.; 4 hours
Result:A dose-responsive reduction of plasma triglycerides desaturation index.
References[1] Sun S, et al. Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors. Bioorg Med Chem. 2015;23(3):455-465. DOI:10.1016/j.bmc.2014.12.014
1H-Pyrazole-3-carboxamide, 5-[1-[(4-fluorophenyl)methyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]-N-(3-pyridinylmethyl)- Preparation Products And Raw materials
Tag:1H-Pyrazole-3-carboxamide, 5-[1-[(4-fluorophenyl)methyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]-N-(3-pyridinylmethyl)-(1282606-48-7) Related Product Information
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