L-Alaninamide, N-[31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacont-1-yl]-L-valyl-N-[(9S)-9-ethyl-2,3,9,10,13,15-hexahydro-9-hydroxy-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]

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L-Alaninamide, N-[31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacont-1-yl]-L-valyl-N-[(9S)-9-ethyl-2,3,9,10,13,15-hexahydro-9-hydroxy-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]- Suppliers list
Company Name: Shanxi Tihondan Pharmaceutical Technology Co., Ltd
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Products Intro: Product Name:1-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)-N-((S)-1-(((S)-1-(((S)-9-ethyl-9-hydroxy-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amide
CAS:2495742-34-0
Purity:95%+ Package:5g;10g;1kg;10kg
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Products Intro: Product Name:Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan
CAS:2495742-34-0
Package:50mg;|5mg;
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Products Intro: Product Name:1-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)-N-((S)-1-(((S)-1-(((S)-9-ethyl-9-hydroxy-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amide
CAS:2495742-34-0
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Products Intro: Product Name:Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan
CAS:2495742-34-0
Purity:98% Package:1g;10g;100g
Company Name: Shanghai Tekanbio Pharm-Tech Co., Ltd.  
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Products Intro: Product Name:Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan
CAS:2495742-34-0
Purity:>95% Package:1g;100mg Remarks:AZ-0133

L-Alaninamide, N-[31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacont-1-yl]-L-valyl-N-[(9S)-9-ethyl-2,3,9,10,13,15-hexahydro-9-hydroxy-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]- manufacturers
L-Alaninamide, N-[31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacont-1-yl]-L-valyl-N-[(9S)-9-ethyl-2,3,9,10,13,15-hexahydro-9-hydroxy-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]- Basic information
Product Name:L-Alaninamide, N-[31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacont-1-yl]-L-valyl-N-[(9S)-9-ethyl-2,3,9,10,13,15-hexahydro-9-hydroxy-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]-
Synonyms:1-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)-N-((S)-1-(((S)-1-(((S)-9-ethyl-9-hydroxy-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amide;Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan;L-Alaninamide, N-[31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacont-1-yl]-L-valyl-N-[(9S)-9-ethyl-2,3,9,10,13,15-hexahydro-9-hydroxy-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]-
CAS:2495742-34-0
MF:C57H77N7O18
MW:1148.26
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Mol File:2495742-34-0.mol
L-Alaninamide, N-[31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacont-1-yl]-L-valyl-N-[(9S)-9-ethyl-2,3,9,10,13,15-hexahydro-9-hydroxy-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]- Structure
L-Alaninamide, N-[31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacont-1-yl]-L-valyl-N-[(9S)-9-ethyl-2,3,9,10,13,15-hexahydro-9-hydroxy-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]- Chemical Properties
Boiling point 1348.9±65.0 °C(Predicted)
density 1.36±0.1 g/cm3(Predicted)
pka11.21±0.20(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
L-Alaninamide, N-[31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacont-1-yl]-L-valyl-N-[(9S)-9-ethyl-2,3,9,10,13,15-hexahydro-9-hydroxy-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]- Usage And Synthesis
UsesMal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan is a Drug-Linker Conjugates for ADC, which comprises a topoisomerase inhibitor and a linker for ligand unit connecting. Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan can be used to synthesis antibody-drug conjugate (ADC)[1].
IC 50Camptothecins
References[1] Schmidt, et al. Computer-based scoring method indicating a cancer patient's response to an anti-B7H4 antibody-drug conjugate therapy using a convolutional neural network, WO2022053685, 2022.
[2] Philip Wilson Howard, et al. Compounds and conjugates thereof. Patent US20200306243A1.
L-Alaninamide, N-[31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacont-1-yl]-L-valyl-N-[(9S)-9-ethyl-2,3,9,10,13,15-hexahydro-9-hydroxy-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]- Preparation Products And Raw materials
Tag:L-Alaninamide, N-[31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacont-1-yl]-L-valyl-N-[(9S)-9-ethyl-2,3,9,10,13,15-hexahydro-9-hydroxy-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]-(2495742-34-0) Related Product Information