| Company Name: |
Apextide Co Ltd Gold |
| Tel: |
15300650552; 15300650552 |
| Email: |
info@apextide.com |
Inclisiran sodium manufacturers
- Inclisiran sodium
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- $2.00
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2026-08-25
- CAS:1639324-58-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
- Inclisiran
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2026-07-22
- CAS:1639324-58-5
- Min. Order: 1kg
- Purity: 98
- Supply Ability: 1000kgs
- Inclisiran
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- $1400.00
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2026-04-21
- CAS:1639324-58-5
- Min. Order: 10g
- Purity: 98%HPLC；99%HPLC
- Supply Ability: 10kg
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| | Inclisiran sodium Basic information |
| Product Name: | Inclisiran sodium | | Synonyms: | Inclisiran sodium;ALN-PCSsc;Ingersoll Rand;(2R,3S,3aS,9aR)-3-hydroxy-2,5-bis(hydroxymethyl)-2,3,3a,9a-tetrahydrofuro[3',2':4,5]imidazo[1,2-c]pyrimidine-6,8(4H,7H)-dione;Inclisiran;RNA, (Am-sp-(2′-deoxy-2′-fluoro)C-sp-Am-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)A-Gm-(2′-deoxy-2′-fluoro)C-Am-(2′-deoxy-2′-fluoro)A-Am-(2′-deoxy-2′-fluoro)A-Cm-(2′-deoxy-2′-fluoro)A-Gm-(2′-deoxy-2′-fluoro)G-Um-(2′-deoxy-2′-fluoro)C-Um-Am-Gm-sp-Am-sp-Am), complex with RNA (Cm-sp-Um-sp-Am-Gm-Am-Cm-(2′-deoxy-2′-fluoro)C-Um-(2′-deoxy-2′-fluoro)G-Um-dT-Um-Um-Gm-Cm-Um-Um-Um-Um-Gm-Um) 3′-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl | | CAS: | 1639324-58-5 | | MF: | | | MW: | 0 | | EINECS: | 200-000-0 | | Product Categories: | APIs;siRNA | | Mol File: | Mol File | ![Inclisiran sodium Structure]() |
| | Inclisiran sodium Chemical Properties |
| storage temp. | Store at -20°C | | form | Solid | | color | White to off-white | | Sequence | RNA, (Am-sp-(2'-deoxy-2'-fluoro)C-sp-Am-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'- fluoro)A-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)AAm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-Am-Gm-sp-Am-sp-Am), complex with RNA (Cm-sp-Umsp -Am-Gm-Am-Cm-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Um-dT-UmUm-Gm-Cm-Um-Um-Um-Um-Gm-Um) 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2- deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-βD-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]- 1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2- pyrrolidinyl]methyl hydrogen phosphate] (1:1) |
| | Inclisiran sodium Usage And Synthesis |
| History | Inclisiran sodium, brand name Leqvio, is a medicine used to reduce cholesterol in the blood. Inclisiran is being developed by The Medicines Company, a subsidiary of Novartis, which licensed the rights to inclisiran from Alnylam Pharmaceuticals.
Inclisiran was approved for use in the European Union in December 2020. In August 2021, it received NICE approval for use by the National Health Service in the UK. In December 2021, it was approved for medical use in the United States. The U.S. Food and Drug Administration considers it to be a first-in-class medication. In August 2023, the National Medical Products Administration approved the use of inclisiran in China. | | Uses | Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK9. Inclisiran can be used for hyperlipidemia and cardiovascular disease (CVD) research[1]. | | References | [1] Constantine E Kosmas, et al. Inclisiran for the Treatment of Cardiovascular Disease: A Short Review on the Emerging Data and Therapeutic Potential. Ther Clin Risk Manag. 2020 Oct 28;16:1031-1037. DOI:10.2147/TCRM.S230592
[2] Kong N, Xu Q, Cui W, Feng X, Gao H. PCSK9 inhibitor inclisiran for treating atherosclerosis via regulation of endothelial cell pyroptosis. Ann Transl Med. 2022;10(22):1205. DOI:10.21037/atm-22-4652 |
| | Inclisiran sodium Preparation Products And Raw materials |
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