VESTIPITANT manufacturers
- Vestipitant
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- $2800.00
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2026-05-11
- CAS:334476-46-9
- Purity:
- Supply Ability: 10g
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| | VESTIPITANT Basic information |
| Product Name: | VESTIPITANT | | Synonyms: | VESTIPITANT;(2S)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperazine-1-carboxamide;1-Piperazinecarboxamide, N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methyl-, (2S)-;(S)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-2-(4-fluoro-2-methylphenyl)-N-methylpiperazine-1-carboxamide | | CAS: | 334476-46-9 | | MF: | C23H24F7N3O | | MW: | 491.45 | | EINECS: | | | Product Categories: | | | Mol File: | 334476-46-9.mol |  |
| | VESTIPITANT Chemical Properties |
| Boiling point | 484.1±45.0 °C(Predicted) | | density | 1.299±0.06 g/cm3(Predicted) | | pka | 7.92±0.40(Predicted) |
| | VESTIPITANT Usage And Synthesis |
| Uses | Vestipitant (GW597599) is a neurokinin-1 receptor antagonist (pKi: 9.4, hNK1) with hypnotic effects and the ability to suppress primary insomnia. Vestipitant can effectively block substance P-mediated extracellular regulated kinase phosphorylation and relieve anxiety and possible depression induced by the agonist GR73632 (HY-P1192) in gerbils. Vestipitant can also improve functional dyspnea, anxiety, insomnia, irritable bowel disease, gastroesophageal reflux disease, tinnitus and antiemetic effects[1][2][3]. | | IC 50 | hNK1: 9.4 (pKi) | | References | [1] Ratti E, et al. Efficacy of vestipitant, a neurokinin-1 receptor antagonist, in primary insomnia. Sleep. 2013 Dec 1;36(12):1823-30. DOI:10.5665/sleep.3208
[2] Kranke P, et al. Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron. Br J Anaesth. 2015 Mar;114(3):423-9. DOI:10.1093/bja/aeu376
[3] Brocco M, et al. Cellular and behavioural profile of the novel, selective neurokinin1 receptor antagonist, vestipitant: a comparison to other agents. Eur Neuropsychopharmacol. 2008 Oct;18(10):729-50. DOI:10.1016/j.euroneuro.2008.06.002 |
| | VESTIPITANT Preparation Products And Raw materials |
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