1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (R)- (9CI) manufacturers
- TISCH
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- $1980.00
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2026-05-11
- CAS:131615-52-6
- Purity:
- Supply Ability: 10g
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| | 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (R)- (9CI) Basic information |
| Product Name: | 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (R)- (9CI) | | Synonyms: | 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (R)- (9CI);TISCH | | CAS: | 131615-52-6 | | MF: | C17H17ClINO | | MW: | 413.68 | | EINECS: | | | Product Categories: | | | Mol File: | 131615-52-6.mol |  |
| | 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (R)- (9CI) Chemical Properties |
| Boiling point | 471.8±45.0 °C(Predicted) | | density | 1.580±0.06 g/cm3(Predicted) | | pka | 8.81±0.40(Predicted) |
| | 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (R)- (9CI) Usage And Synthesis |
| Uses | TISCH is a potent and selective iodinated ligand with high affinity and selectivity for CNS D1 dopamine receptors. TISCH showed a Kd value of 0.205 nM in rat striatal tissue, indicating its effectiveness in biological activity. TISCH is able to easily cross the blood-brain barrier and show distribution in specific areas with D1 receptor density. TISCH is considered to be useful as a pharmacological tool for characterizing D1 dopamine receptors. When labeled with I-123, TISCH has the potential to be used as an in vivo imaging agent for CNS D1 dopamine receptors[1]. | | References | [1] Synthesis and resolution of (+-)-7-chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro- 1H-3- benzazepine (TISCH): a high affinity and selective iodinated ligand for CNS D1 dopamine receptor |
| | 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (R)- (9CI) Preparation Products And Raw materials |
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