|
|
| | D-erythro-Sphingosine, D9 Basic information |
| | D-erythro-Sphingosine, D9 Chemical Properties |
| Boiling point | 445.922±45.00 °C(Press: 760.00 Torr)(predicted) | | density | 0.940±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | Chloroform: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | | form | A solid |
| | D-erythro-Sphingosine, D9 Usage And Synthesis |
| Description | Sphingosine-d9 is intended for use as an internal standard for the quantification of sphingosine by GC- or LC-MS. Sphingosine is formed primarily from the breakdown of ceramide.1 Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase.1 Phosphorylation of sphingosine by sphingosine kinases 1 and 2 (SPHK1, SPHK2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.2,3,4 | | Uses | Sphingosine-d9 (d18:1) (D-eytho-Sphigosie C18-d9) is deuterium labeled Sphingosine (d18:1)[1]. | | References | 1. Hannun, Y.A., Luberto, C., and Argraves, K.M. Enzymes of sphingolipid metabolism: From modular to integrative signaling Biochemistry 40(16),4893-4903(2001).
2. Takuwa, Y., Takuwa, N., and Sugimoto, N. The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activities J. Biochem. 131(6),767-771(2002).
3. Ishii, I., Fukushima, N., Ye, X., et al. Lysophospholipid receptors: Signaling and biology Annu. Rev. Biochem. 73,321-354(2004).
4. Kluk, M.J., and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors Biochim. Biophys. Acta 1582(1-3),72-80(2002). |
| | D-erythro-Sphingosine, D9 Preparation Products And Raw materials |
|