2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]-, (2E)-rel-

Request For Quotation

2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]-, (2E)-rel- manufacturers

  • EGFR/HER2-IN-9
  • EGFR/HER2-IN-9 pictures
  • $766.00
  • 2026-05-11
  • CAS:1637253-79-2
  • Purity:
  • Supply Ability: 10g
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]-, (2E)-rel- Basic information
Product Name:2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]-, (2E)-rel-
Synonyms:2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]-, (2E)-rel-;EGFR/HER2-IN-9
CAS:1637253-79-2
MF:C25H25ClFN5O4
MW:513.95
EINECS:
Product Categories:
Mol File:1637253-79-2.mol
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]-, (2E)-rel- Structure
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]-, (2E)-rel- Chemical Properties
Boiling point 717.4±60.0 °C(Predicted)
density 1.405±0.06 g/cm3(Predicted)
pka11.99±0.43(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]-, (2E)-rel- Usage And Synthesis
UsesEGFR/HER2-IN-9 (Compound 1) is an EGFR and HER2 inhibitor with IC50s of 3.2, 8.3 and 14 nM against EGFR, EGFR T790M and HER2, respectively[1].
IC 50EGFR: 3.2 nM (IC50); EGFRT790M: 8.3 nM (IC50); HER2: 14 nM (IC50)
References[1] Yingjun Zhang, et al. Amino quinazoline derivatives as well as salts and application method thereof. Patent CN104119350A.
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]-, (2E)-rel- Preparation Products And Raw materials
Tag:2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]-, (2E)-rel-(1637253-79-2) Related Product Information
EGFR Protein, HUMAN (621A.A, HEK293, FC) EGFR protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI) HER2/CD340 protein, HUMAN (BIOTINYLATED, HEK293, HIS) HER3 Protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI) AZD-9291 Protein Tyrosine Kinase Compound Library