| Company Name: |
Phygene |
| Tel: |
18059081430 |
| Email: |
2070812664@qq.com |
|
| | MMP-13 substrate, fluorogenic Basic information |
| Product Name: | MMP-13 substrate, fluorogenic | | Synonyms: | 390 MMP FRET SUBSTRATE IV;COLLAGENASE-3 SUBSTRATE, FLUOROGENIC;MCA-PRO-CHA-GLY-NVA-HIS-ALA-DAP(DNP)-NH2;MCA-P-CHA-G-NVA-HA-DAP(DNP)-NH2;MCA-PRO-CHA-GLY-NVA-HIS-ALA-DPA-NH2;MMP-13 substrate, fluorogenic | | CAS: | | | MF: | C51H65N13O15 | | MW: | 1100.14 | | EINECS: | | | Product Categories: | peptide | | Mol File: | Mol File |  |
| | MMP-13 substrate, fluorogenic Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: 5mg/mL | | form | lyophilized solid | | color | yellow |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | MMP-13 substrate, fluorogenic Usage And Synthesis |
| Description | Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. 7-methoxycoumarin-4-acetyl (Mca) is released by cleavage of Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2, of which the fluorescence can be used to quantify MMP-1, MMP-3 and MMP-26 activity. | | Uses | Matrix metalloproteinases (MMP) are a family of zinc-dependent endopeptidases th at degrade matrix proteins. MMPs include collagenases, gelatinases, matrilysins, enamelysins, metalloelastases, stromelysins and other structural protein and receptor lysins. The activity of these enzymes is selectively inhibited or measured by appropriately labeled peptides. MCA-Pro-Cha-Gly-Nva-His-Ala-DNP-DPA-NH2 is used as a fluorogenic substrate for matrix metalloprotein-13 (collagenase-3, MMP-13). | | Biological Activity | Primary Target
A quenched fluorescence substrate for MMP-13 (collagenase-3)', 'kcat/Km = 1.09 x 106 M-¹ sec-¹ for MMP-13 (collagenase-3) | | Sequene | Mca-Pro-Cha-Gly-Nva-His-Ala-Dap(Dnp)-NH2 |
| | MMP-13 substrate, fluorogenic Preparation Products And Raw materials |
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