- Betulonic acid
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- $48.00
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2026-06-02
- CAS:4481-62-3
- Purity: 99.70%
- Supply Ability: 10g
- Betulonicacid
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- $10.00
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2026-03-20
- CAS:4481-62-3
- Min. Order: 100KG
- Purity: 99%
- Supply Ability: 100 mt
- Betulonic acid
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- $1.00
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2024-04-22
- CAS:4481-62-3
- Min. Order: 1KG
- Purity: 99.91%
- Supply Ability: 200000
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| | Betulonicacid Basic information |
| | Betulonicacid Chemical Properties |
| Melting point | 253 °C | | Boiling point | 548.1±33.0 °C(Predicted) | | density | 1.061±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) | | form | Solid | | pka | 4.62±0.70(Predicted) | | color | White to Off-White | | Major Application | food and beverages | | InChIKey | SLJTWDNVZKIDAU-SVAFSPIFSA-N | | SMILES | C1(=O)[C@@]([C@]2([C@](C)(CC1)[C@]1([H])[C@@]([C@]3([C@@](CC1)([H])[C@@]1([C@@](CC[C@H]1C(C)=C)(C(O)=O)CC3)[H])C)(C)CC2)[H])(C)C |
| Safety Statements | 24/25 | | WGK Germany | WGK 3 | | HS Code | 29389090 | | Storage Class | 11 - Combustible Solids |
| | Betulonicacid Usage And Synthesis |
| Chemical Properties | Betulin ketoacetic acid in the form of a white crystalline powder is a pentacyclic triterpenoid widely distributed in a variety of plants, and its content in the bark of Betula alba ranges from 0.25 to 2% (in dry form). | | Uses | (+)-Betulonic Acid shows potent cytotoxic activities against PC3, MGC-803, Bcap-37, and MCF-7 cell lines. | | Definition | ChEBI: Betulonic acid is a triterpenoid. It has a role as an anticoronaviral agent. | | Synthesis | General procedure for the synthesis of 3-oxo-lupin-20(29)-en-28-oic acid from betulinic acid:
1. preparation of Jones' reagent: chromium trioxide (CrO3, 26.72 g) was dissolved in concentrated sulfuric acid (H2SO4, 23 ml) and the solution was subsequently diluted to 100 ml with water.
2. Reaction process: Betulinic acid (BA, 500 mg, 1.09 mmol) was dissolved in a solvent mixture of dichloromethane (CH2Cl2, 12 ml) and acetone (12 ml), and Jones reagent (1 ml) was added slowly after cooling.
3. Reaction control: the reaction mixture was stirred at room temperature for 15 min followed by addition of methanol (MeOH, 5 ml) to terminate the reaction. After continued stirring for 10 minutes, the reaction mixture was diluted by adding dichloromethane (CH2Cl2, 20 ml).
4. Post-treatment: The organic layer was washed sequentially with water and saturated sodium chloride (NaCl) solution, dried with anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under vacuum.
5. Purification: the crude product was recrystallized three times in methanol (MeOH) to give 3-oxo lupin-20(29)-en-28-oic acid (462 mg, 93% yield) as a white solid. | | IC 50 | Plasmodium; HSV-1 | | References | [1] Phytochemistry, 1998, vol. 49, # 3, p. 709 - 717
[2] Journal of Asian Natural Products Research, 2014, vol. 16, # 1, p. 34 - 42
[3] Chinese Chemical Letters, 2015, vol. 26, # 6, p. 759 - 762
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3122 - 3134
[5] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 240 - 248 |
| | Betulonicacid Preparation Products And Raw materials |
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