| Company Name: |
Gihi Chemicals Co., Limited
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| Tel: |
+86-0571-86217390 +8618058761490 |
| Email: |
info@gihichem.com |
| Products Intro: |
Product Name:Sevelamer
CAS:52757-95-6
Purity:0.98 Package:100g;500g;1kg;5kg;25kg;Customized by customer
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| | Sevelamer Basic information |
| Product Name: | Sevelamer | | Synonyms: | Sevelamer;2-Propen-1-amine, polymer with (chloromethyl)oxirane;Allylamine polymer with 1-chloro-2,3-epoxypropane;Allylamine-epichlorohydrin copolymer;Hsdb 7608;Oxirane, (chloromethyl)-, polymer with 2-propen-1-amine;Sevelamer [inn:ban];Epichlorohydrin-PAA 25 copolymer | | CAS: | 52757-95-6 | | MF: | C6H12ClNO | | MW: | 149.62 | | EINECS: | | | Product Categories: | | | Mol File: | 52757-95-6.mol |  |
| | Sevelamer Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | Sevelamer Usage And Synthesis |
| Uses | Antihyper-phosphatemic. | | Brand name | Renagel (Genzyme). | | Pharmaceutical Applications | In patients on dialysis, Sevelamer or lanthanum salts can be used to maintain normal phosphate blood levels. Sevelamer is a polymer containing amine
groups. These protonated amine groups can react with the negatively charged phosphate groups via ionic binding
and prevent absorption of phosphate from the gut. Sevelamer is a hydrogel containing cross-linked polyallylamine chains. The negatively charged phosphate can be bound to the positively charged amine groups of the hydrogel in the intestines and removed via the faeces. | | Clinical Use | Phosphate-binding agent | | Drug interactions | Potentially hazardous interactions with other drugs
Antibacterials: reduces bioavailability of
ciprofloxacin.
Ciclosporin: possibly reduces ciclosporin
concentration.
Calcitriol: absorption may be impaired by sevelamer.
Mycophenolate: may reduce mycophenolate levels.
Tacrolimus: possibly reduces tacrolimus
concentration.
Thyroid hormones: possibly reduces levothyroxine
concentration. | | Metabolism | Sevelamer is not systemically absorbed. |
| | Sevelamer Preparation Products And Raw materials |
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