8,10,12,14,19-Docosapentaenoic acid, 7,16,17-trihydroxy-, (7S,8E,10Z,12E,14E,16R,17S,19Z)-

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8,10,12,14,19-Docosapentaenoic acid, 7,16,17-trihydroxy-, (7S,8E,10Z,12E,14E,16R,17S,19Z)- manufacturers
8,10,12,14,19-Docosapentaenoic acid, 7,16,17-trihydroxy-, (7S,8E,10Z,12E,14E,16R,17S,19Z)- Basic information
Product Name:8,10,12,14,19-Docosapentaenoic acid, 7,16,17-trihydroxy-, (7S,8E,10Z,12E,14E,16R,17S,19Z)-
Synonyms:8,10,12,14,19-Docosapentaenoic acid, 7,16,17-trihydroxy-, (7S,8E,10Z,12E,14E,16R,17S,19Z)-;Resolvin D2 n-3 DPA
CAS:2093111-29-4
MF:C22H34O5
MW:378.5
EINECS:
Product Categories:
Mol File:2093111-29-4.mol
8,10,12,14,19-Docosapentaenoic acid, 7,16,17-trihydroxy-, (7S,8E,10Z,12E,14E,16R,17S,19Z)- Structure
8,10,12,14,19-Docosapentaenoic acid, 7,16,17-trihydroxy-, (7S,8E,10Z,12E,14E,16R,17S,19Z)- Chemical Properties
Boiling point 607.6±55.0 °C(Predicted)
density 1.087±0.06 g/cm3(Predicted)
storage temp. -80°C
solubility Ethanol: 1 mg/ml
pka4.76±0.10(Predicted)
Safety Information
MSDS Information
8,10,12,14,19-Docosapentaenoic acid, 7,16,17-trihydroxy-, (7S,8E,10Z,12E,14E,16R,17S,19Z)- Usage And Synthesis
UsesResolvin D2 n-3 DPA is a specialized proresolving mediator (SPM). Resolvin D2 n-3 DPA (1 nM) can reduce the chemotaxis and adhesion of human neutrophils induced by TNF-α. Resolvin D2 n-3 DPA (100 ng/mouse; intravenous injection) can reduce neutrophil infiltration in the peritoneum and the levels of IL-6 and the chemokine (C-C motif) ligand 2 (CCL2) in a mouse model of inflammation induced by zinc oxide[1].
Biological ActivityResolvin D2 n-3 DPA (RvD2 n-3 DPA) is a specialized pro-resolving mediator (SPM).1 It is formed from docosapentaenoic acid , an intermediate in the conversion of eicosapentaenoic acid to docosahexaenoic acid , in human leukocytes. RvD2 n-3 DPA (1 nM) reduces TNF-α-induced chemotaxis and adhesion of isolated human neutrophils. In vivo, RvD2 n-3 DPA (100 ng/animal; i.v.) reduces peritoneal neutrophil infiltration and exudate levels of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in a mouse model of zymosan-induced inflammation.
References1.Dalli, J., Colas, R.A., and Serhan, C.N.Novel n-3 immunoresolvents: Structures and actionsSci. Rep.31940(2013)
8,10,12,14,19-Docosapentaenoic acid, 7,16,17-trihydroxy-, (7S,8E,10Z,12E,14E,16R,17S,19Z)- Preparation Products And Raw materials
Tag:8,10,12,14,19-Docosapentaenoic acid, 7,16,17-trihydroxy-, (7S,8E,10Z,12E,14E,16R,17S,19Z)-(2093111-29-4) Related Product Information
Resolvin D5 MQCKXANXFRGFND-CGIARSFXSA-N JUBMLVBCKBUAQW-STWMVWSJSA-N Resolvin D2 IKFAUGXNBOBQDM-XNSNRJMHSA-N Infliximab