[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-4(7H)-ACETAMIDE, N-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENYL]-2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-5-ETHYL-6-[4-[(5-HYDROXY-6-METHYL-4-PYRIM
概述 用途与合成方法 MSDS [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-4(7H)-ACETAMIDE, N-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENYL]-2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-5-ETHYL-6-[4-[(5-HYDROXY-6-METHYL-4-PYRIM价格(试剂级) 上下游产品信息
| 中文名称 | [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-4(7H)-ACETAMIDE, N-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENYL]-2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-5-ETHYL-6-[4-[(5-HYDROXY-6-METHYL-4-PYRIM |
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| 中文同义词 | [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-4(7H)-ACETAMIDE, N-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENYL]-2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-5-ETHYL-6-[4-[(5-HYDROXY-6-METHYL-4-PYRIM;1,2,4]三唑并[1,5-A]嘧啶-4(7H)-乙酰胺,N-[2-氯-4-(三氟甲基)苯基]-2-(3,6-二氢-2H-吡喃-4-基)-5-乙基-6-[4-[(5-羟基-6-甲基-4-吡喃;N-(2-氯-4-(三氟甲基)苯基)-2-(2-(3,6-二氢-2H-吡喃-4-基)-5-乙基-6-(4-(5-羟基-6-甲基嘧啶-4-羰基)哌嗪-1-基)-7-氧代-[1,2,4]三唑并[1,5-A]嘧啶-4(7H)-基)乙酰胺;[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-4(7H)-ACETAMIDE, N-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENYL]-2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-5-ETHYL-6-[4-[(5-HYDROXY-6-METHYL-4-PYR;WERNER 综合征 RECQ 解旋酶-IN-1,10 MM DMSO 溶液;WERNER 综合征 RECQ 解旋酶-IN-1 |
| 英文名称 | [1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo- |
| 英文同义词 | [1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo-;Werner syndrome RecQ helicase-IN-1;N-(2-chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(5-hydroxy-6-methylpyrimidine-4-carbonyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)acetamide;Werner syndrome RecQ helicase-IN-1, 10 mM in DMSO;N-(2-chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(5-hydroxy-6-methylpyrimidine-4-carbonyl)azine-1-yl)-7-oxy-[1,2,4]triazolebenzo[1,5-a]pyrimidine-4(7H)-yl)acetamide;RHO761;Werner syndrome RecQ helicase-IN-1 HRO761 |
| CAS号 | 2869954-34-5 |
| 分子式 | C31H31ClF3N9O5 |
| 分子量 | 702.08 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2869954-34-5.mol |
| 结构式 | ![[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-4(7H)-ACETAMIDE, N-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENYL]-2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-5-ETHYL-6-[4-[(5-HYDROXY-6-METHYL-4-PYRIM 结构式](CAS/20210305/GIF/2869954-34-5.gif) |
[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-4(7H)-ACETAMIDE, N-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENYL]-2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-5-ETHYL-6-[4-[(5-HYDROXY-6-METHYL-4-PYRIM 性质
| 密度 | 1.58±0.1 g/cm3(Predicted) |
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| 溶解度 | DMSO: Slightly soluble: 0.1-1 mg/ml |
| 酸度系数(pKa) | 5.87±0.45(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至浅黄色 |
| InChIKey | XKYVECRUZPCRQR-UHFFFAOYSA-N |
| SMILES | C12=NC(C3=CCOCC3)=NN1C(=O)C(N1CCN(C(C3C(O)=C(C)N=CN=3)=O)CC1)=C(CC)N2CC(NC1=CC=C(C(F)(F)F)C=C1Cl)=O |
[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-4(7H)-ACETAMIDE, N-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENYL]-2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-5-ETHYL-6-[4-[(5-HYDROXY-6-METHYL-4-PYRIM 用途与合成方法
HRO761 (Werner syndrome RecQ helicase-IN-1) (example 42)是一种有效的 Werne r综合征 RecQ DNA 解旋酶 (WRN) 抑制剂，可用于癌症研究。