2-Pyridinecarboxamide, 5-[2-(5-isoquinolinyl)ethynyl]-N-[4-(4-morpholinylmethyl)-3-(trifluoromethyl)phenyl]-

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2-Pyridinecarboxamide, 5-[2-(5-isoquinolinyl)ethynyl]-N-[4-(4-morpholinylmethyl)-3-(trifluoromethyl)phenyl]- Basic information
Product Name:2-Pyridinecarboxamide, 5-[2-(5-isoquinolinyl)ethynyl]-N-[4-(4-morpholinylmethyl)-3-(trifluoromethyl)phenyl]-
Synonyms:2-Pyridinecarboxamide, 5-[2-(5-isoquinolinyl)ethynyl]-N-[4-(4-morpholinylmethyl)-3-(trifluoromethyl)phenyl]-;MTH1 activator-1
CAS:2803422-60-6
MF:C29H23F3N4O2
MW:516.51
EINECS:
Product Categories:
Mol File:2803422-60-6.mol
2-Pyridinecarboxamide, 5-[2-(5-isoquinolinyl)ethynyl]-N-[4-(4-morpholinylmethyl)-3-(trifluoromethyl)phenyl]- Structure
2-Pyridinecarboxamide, 5-[2-(5-isoquinolinyl)ethynyl]-N-[4-(4-morpholinylmethyl)-3-(trifluoromethyl)phenyl]- Chemical Properties
Boiling point 602.0±55.0 °C(Predicted)
density 1.39±0.1 g/cm3(Predicted)
pka10.75±0.70(Predicted)
Safety Information
MSDS Information
2-Pyridinecarboxamide, 5-[2-(5-isoquinolinyl)ethynyl]-N-[4-(4-morpholinylmethyl)-3-(trifluoromethyl)phenyl]- Usage And Synthesis
UsesMTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. MTH1 activator-1 can be used to probe the cellular and biological effects of upregulated oxidative damage repair in nucleotide pools and to delay or abrogate tumorigenesis[1].
References[1] Lee Y, et al. Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1. ACS Chem Biol. 2022 Aug 19;17(8):2074-2087. DOI:10.1021/acschembio.2c00038
2-Pyridinecarboxamide, 5-[2-(5-isoquinolinyl)ethynyl]-N-[4-(4-morpholinylmethyl)-3-(trifluoromethyl)phenyl]- Preparation Products And Raw materials
Tag:2-Pyridinecarboxamide, 5-[2-(5-isoquinolinyl)ethynyl]-N-[4-(4-morpholinylmethyl)-3-(trifluoromethyl)phenyl]-(2803422-60-6) Related Product Information
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