| Company Name: |
Cochemical Ltd. |
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029-86115547 17791676824 |
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sales@cochemical.com |
3-Pyridinemethanamine,6-fluoro-(9CI) manufacturers
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| | 3-Pyridinemethanamine,6-fluoro-(9CI) Basic information |
| Product Name: | 3-Pyridinemethanamine,6-fluoro-(9CI) | | Synonyms: | (6-Fluoropyridin-3-yl);5-(Aminomethyl)-2-fluoropyridine;3-Pyridinemethanamine,6-fluoro-(9CI);6-Fluoro-3-pyridineMethanaMine;2-fluoro-5-(aminomethyl)pyridine;3-(Aminomethyl)-6-fluoropyridine;3-Pyridinemethanamine, 6-fluoro-;2-fluoro-5-pyridylmethylamine | | CAS: | 205744-17-8 | | MF: | C6H7FN2 | | MW: | 126.13 | | EINECS: | | | Product Categories: | PYRIDINE | | Mol File: | 205744-17-8.mol |  |
| | 3-Pyridinemethanamine,6-fluoro-(9CI) Chemical Properties |
| Boiling point | 63-65 °C(Press: 0.56 Torr) | | density | 1.180±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 7.73±0.29(Predicted) | | Appearance | Colorless to light yellow Liquid | | InChI | InChI=1S/C6H7FN2/c7-6-2-1-5(3-8)4-9-6/h1-2,4H,3,8H2 | | InChIKey | KYRWSLUCAPNJPI-UHFFFAOYSA-N | | SMILES | C1=NC(F)=CC=C1CN |
| | 3-Pyridinemethanamine,6-fluoro-(9CI) Usage And Synthesis |
| Uses | 6-Fluoro-3-pyridinemethanamine is a useful compound for the study of herbicidal activity of 2-cyano-3-[[(6-fluoro-3-pyridinyl)methyl]amino]acrylates. | | Synthesis | General procedure for the synthesis of (6-fluoropyridin-3-yl)methanamine from 6-fluoro-3-cyanopyridine: 6-fluoro-3-cyanopyridine (300 mg, 2.46 mmol) was dissolved in 2 mol/L ammonia/methanol solution (30 mL), nickel Ruanne (0.5 g) was added at room temperature and the reaction was carried out for 12 h under hydrogen atmosphere. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and washed with methanol (5 mL x 2). The filtrate was concentrated to dryness and the residue was purified by silica gel column chromatography (eluent ratio of dichloromethane: methanol = 100:4) to give 262 mg of yellow oily solid in 85% yield. | | References | [1] Patent: CN106916101, 2017, A. Location in patent: Paragraph 0149; 0150
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 19, p. 7965 - 7983 |
| | 3-Pyridinemethanamine,6-fluoro-(9CI) Preparation Products And Raw materials |
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