1H-Benzimidazole-2-methanol,5-nitro-(9CI) manufacturers
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| | 1H-Benzimidazole-2-methanol,5-nitro-(9CI) Basic information | | Application |
| Product Name: | 1H-Benzimidazole-2-methanol,5-nitro-(9CI) | | Synonyms: | 1H-Benzimidazole-2-methanol,5-nitro-(9CI);1H-BenziMidazole-2-Methanol, 6-nitro-;5-Nitro-1H-benziMidazole-2-Methanol;(5-Nitrobenzimidazol-2-yl)methanol;(5-Nitro-1H-1,3-benzodiazol-2-yl)methanol;5-Nitro-2-benzimidazolemethanol;(6-nitro-1H-benzimidazol-2-yl)methanol;(6-nitro-1H-benzo[d]imidazol-2-yl)methanol | | CAS: | 20034-00-8 | | MF: | C8H7N3O3 | | MW: | 193.16 | | EINECS: | | | Product Categories: | BENZIMIDAZOLE | | Mol File: | 20034-00-8.mol |  |
| | 1H-Benzimidazole-2-methanol,5-nitro-(9CI) Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | Appearance | White to off-white Solid | | InChI | InChI=1S/C8H7N3O3/c12-4-8-9-6-2-1-5(11(13)14)3-7(6)10-8/h1-3,12H,4H2,(H,9,10) | | InChIKey | ZJLPIDVKNQXTKN-UHFFFAOYSA-N | | SMILES | C1(CO)NC2=CC([N+]([O-])=O)=CC=C2N=1 |
| | 1H-Benzimidazole-2-methanol,5-nitro-(9CI) Usage And Synthesis |
| Application | 5-Nitro-1H-benzimidazole-2-methanol can be used as an organic intermediate and pharmaceutical intermediate, mainly in laboratory research and development processes and chemical production processes. | | Synthesis | GENERAL METHOD: 4-nitrophthalamide (10 mmol) was mixed with ethanoic acid (2.28 g, 30 mmol) in a reaction flask and concentrated phosphoric acid (20 mL) was added as a catalyst. The reaction mixture was heated to 130 °C and kept at reflux for 3 hours. Upon completion of the reaction, the reaction was quenched with 20% sodium hydroxide solution. The resulting 5-nitro-1H-benzimidazole-2-methanol solid product was separated and collected by filtration. | | References | [1] Russian Journal of General Chemistry, 2017, vol. 87, # 12, p. 3006 - 3016
[2] Bulletin of the Korean Chemical Society, 2013, vol. 34, # 4, p. 1272 - 1274
[3] Molecules, 2015, vol. 20, # 8, p. 15206 - 15223
[4] Journal of the American Chemical Society, 1952, vol. 74, p. 3689
[5] Journal of the American Chemical Society, 1957, vol. 79, p. 4391,4393 |
| | 1H-Benzimidazole-2-methanol,5-nitro-(9CI) Preparation Products And Raw materials |
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