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| | 2-Methoxy-6-methylaminopyridine Basic information |
| | 2-Methoxy-6-methylaminopyridine Chemical Properties |
| Boiling point | 156/759mm | | density | 1.01 | | refractive index | 1.4995 | | Fp | 156°C | | storage temp. | Inert atmosphere,Room Temperature | | pka | 4.12±0.10(Predicted) | | form | clear liquid | | color | Colorless to Light yellow | | Water Solubility | Slightly soluble in water. | | CAS DataBase Reference | 63071-03-4(CAS DataBase Reference) |
| | 2-Methoxy-6-methylaminopyridine Usage And Synthesis |
| Uses | 2-Methoxy-6-methylpyridine is used as a pharmaceutical intermediate. | | Synthesis | 1) A mixture of 2-hydroxy-6-methylpyridine (164 g, 1.47 mol), iodomethane (1.35 kg, 9.53 mol) and Ag2CO3 (526 g, 1.91 mol) in THF (10 mL) was stirred at ambient temperature for 1 hr under light-avoiding conditions.2) Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the mixture was washed with THF The filter cake was washed with THF. 3) The filtrates were combined and concentrated in vacuum until complete removal of methyl iodide was confirmed by HPLC analysis to give 145.6 g of 2-methoxy-6-methylpyridine in 80% yield. | | References | [1] Tetrahedron Letters, 1997, vol. 38, # 35, p. 6153 - 6156
[2] Synthetic Communications, 1994, vol. 24, # 10, p. 1367 - 1379
[3] Tetrahedron, 2000, vol. 56, # 20, p. 3181 - 3187
[4] Patent: US2006/287292, 2006, A1. Location in patent: Page/Page column 28
[5] Patent: US2007/281918, 2007, A1. Location in patent: Page/Page column 13 |
| | 2-Methoxy-6-methylaminopyridine Preparation Products And Raw materials |
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