HIF-1α-IN-5

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HIF-1α-IN-5 Suppliers list
Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
Tel: 15865264761
Email: 486064515@qq.com
Company Name: Henan Yinuokai New Materials Co., Ltd  
Tel: 15565215982 15565215982
Email: 15565215982@163.com
HIF-1α-IN-5 Basic information
Product Name:HIF-1α-IN-5
Synonyms:HIF-1α-IN-5;1,2-Benzisoxazole-3-carboxamide, N-[4-(dimethylamino)phenyl]-
CAS:2826221-10-5
MF:C16H15N3O2
MW:281.31
EINECS:
Product Categories:
Mol File:2826221-10-5.mol
HIF-1α-IN-5 Structure
HIF-1α-IN-5 Chemical Properties
Boiling point 395.096±22.00 °C(Press: 760.00 Torr)(predicted)
density 1.300±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka10.790±0.70(predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
HIF-1α-IN-5 Usage And Synthesis
UsesHIF-1α-IN-5 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell). HIF-1α-IN-5 also inhibits MAO-A activity. HIF-1α-IN-5 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-5 can be used in the research of cancer[1].
References[1] Zian Xue, et al. Benzo[d]isoxazole Derivatives as Hypoxia-Inducible Factor (HIF)-1α Inhibitors. ACS Med. Chem. Lett. 2022.
HIF-1α-IN-5 Preparation Products And Raw materials
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