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Product Name:Phyllomedusin
CAS:26145-48-2
Purity:99% HPLC MS Package:1mg;10mg;100mg
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Enzo Biochem Inc
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Product Name:Phyllomedusin
CAS:26145-48-2
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Product Name:Phyllomedusin
CAS:26145-48-2
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| Products Intro: |
Product Name:Phyllomedusin
CAS:26145-48-2
Purity:98% HPLC Package:10mg;100mg;1000mg
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| | phyllomedusin Basic information |
| Product Name: | phyllomedusin | | Synonyms: | L-Methioninamide, 5-oxo-L-prolyl-L-asparaginyl-L-prolyl-L-asparaginyl-L-arginyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl- | | CAS: | 26145-48-2 | | MF: | C52H82N16O13S | | MW: | 1171.37 | | EINECS: | | | Product Categories: | | | Mol File: | 26145-48-2.mol |  |
| | phyllomedusin Chemical Properties |
| density | 1.47±0.1 g/cm3(Predicted) | | pka | 13.11±0.20(Predicted) |
| | phyllomedusin Usage And Synthesis |
| Uses | Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus[1][2][3]. | | in vivo | Phyllomedusin (30-300 μg/kg, i.p.) delays gastric emptying in conscious rats[2].
Phyllomedusin (0.1 and 5 μg/kg, i.v.) has stimulant activity on the stomach of the anaesthetized rat[3].
| Animal Model: | Conscious rats[2].
| | Dosage: | 30, 100, 300 μg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Caused 75% delay in gastric emptying in conscious rats. |
| | IC 50 | NK1 | | References | [1] Ganjiwale AD, et al. Three-dimensional structure of Phyllomedusin, a NK1 receptor agonist bound to dodecylphosphocholine micelles. J Struct Biol. 2009 Aug;167(2):176-84. DOI:10.1016/j.jsb.2009.04.008
[2] Bertaccini G, et al. Effect of substance P and its natural analogues on gastric emptying of the conscious rat. Br J Pharmacol. 1981 Feb;72(2):221-3. DOI:10.1111/j.1476-5381.1981.tb09116.x
[3] Bertaccini G, et al. Action of some natural peptides on the stomach of the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):163-6. DOI:10.1007/BF00508624
[4] Sacco MA, et al. Kambo: Natural drug or potential toxic agent A literature review of acute poisoning cases. Toxicol Rep. 2022 Apr 15;9:905-913. DOI:10.1016/j.toxrep.2022.04.005 |
| | phyllomedusin Preparation Products And Raw materials |
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