N-[(3S)-3-(2-Chloro-5-fluorophenyl)-6-(5-cyano[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-3-fluoro-5-(trifluoromethyl)benzamide

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N-[(3S)-3-(2-Chloro-5-fluorophenyl)-6-(5-cyano[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-3-fluoro-5-(trifluoromethyl)benzamide Suppliers list
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N-[(3S)-3-(2-Chloro-5-fluorophenyl)-6-(5-cyano[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-3-fluoro-5-(trifluoromethyl)benzamide Basic information
Product Name:N-[(3S)-3-(2-Chloro-5-fluorophenyl)-6-(5-cyano[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-3-fluoro-5-(trifluoromethyl)benzamide
Synonyms:N-[(3S)-3-(2-Chloro-5-fluorophenyl)-6-(5-cyano[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-3-fluoro-5-(trifluoromethyl)benzamide;(S)-RLY-2608;(S)-N-(3-(2-Chloro-5-fluorophenyl)-6-(5-cyano-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1-oxoisoindolin-4-yl)-3-fluoro-5-(trifluoromethyl)benzamide;N-[(3S)-3-(2-chloro-5-fluoro-phenyl)-6-(5-cyano-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1-oxo-isoindolin-4-yl]-3-fluoro-5-(trifluoromethyl)benzamide;(S)-Zovegalisib
CAS:2733573-93-6
MF:C29H14ClF5N6O2
MW:608.91
EINECS:
Product Categories:
Mol File:2733573-93-6.mol
N-[(3S)-3-(2-Chloro-5-fluorophenyl)-6-(5-cyano[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-3-fluoro-5-(trifluoromethyl)benzamide Structure
N-[(3S)-3-(2-Chloro-5-fluorophenyl)-6-(5-cyano[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-3-fluoro-5-(trifluoromethyl)benzamide Chemical Properties
density 1.61±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka11.06±0.40(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
N-[(3S)-3-(2-Chloro-5-fluorophenyl)-6-(5-cyano[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-3-fluoro-5-(trifluoromethyl)benzamide Usage And Synthesis
Uses(S)-RLY-2608 is an S-enantiomer of of RLY-2608 (HY-153306). RLY-2608 is an orally active first-in-class allosteric mutant-selective inhibitor of PI3Ka with anti-tumor activity[1].
References[1] Andreas Varkaris, et al. Discovery and clinical proof-of-concept of RLY-2608, a first-in-class mutant-selective allosteric PI3Ka inhibitor that decouples anti-tumor activity from hyperinsulinemia. Cancer Discov. 2023 Nov 2. DOI:10.1158/2159-8290.CD-23-0944
N-[(3S)-3-(2-Chloro-5-fluorophenyl)-6-(5-cyano[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-3-fluoro-5-(trifluoromethyl)benzamide Preparation Products And Raw materials
Tag:N-[(3S)-3-(2-Chloro-5-fluorophenyl)-6-(5-cyano[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-3-fluoro-5-(trifluoromethyl)benzamide(2733573-93-6) Related Product Information
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