A 62198 manufacturers
- A 62198
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- $3400.00
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2026-05-11
- CAS:117978-26-4
- Purity:
- Supply Ability: 10g
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| | A 62198 Basic information |
| Product Name: | A 62198 | | Synonyms: | 5-Azido-1-cyclohexyl-1,2,5-trideoxy-2-[[N-[N-(2-methyl-1-oxopropyl)-L-phenylalanyl]-L-histidyl]amino]-L-arabino-pentitol;A 62198;N-[1-[[1-[(5-azido-1-cyclohexyl-3,4-dihydroxy-pentan-2-yl)carbamoyl]-2-(3H-imidazol-4-yl)ethyl]carbamoyl]-2-phenyl-ethyl]-2-methyl-propanamide;Reaxys ID: 26144718 | | CAS: | 117978-26-4 | | MF: | C30H44N8O5 | | MW: | 596.72 | | EINECS: | | | Product Categories: | | | Mol File: | 117978-26-4.mol |  |
| | A 62198 Chemical Properties |
| pka | 13.183±0.20(predicted) |
| | A 62198 Usage And Synthesis |
| Description | A 62198 is a potent and selective renin inhibitor. A-62198 induced a dose-dependent fall in mean arterial blood pressure (MAP) when administered as an i.v. bolus to anesthetized, salt-depleted monkeys. It has potential as a hypotensive agent. | | Uses | A-62198 is a potent and selective renin inhibitor with antihypertensive activity. A-62198 reduces mean arterial pressure (MAP) in anesthetized, salt-deprived monkeys in a dose-dependent manner. A-62198 induced MAP reduction in normal monkeys that reached statistical significance at the highest dose and significantly inhibited plasma renin activity (PRA) at all doses[1]. | | References | [1] Cardiovascular actions of the primate-selective renin inhibitor, A-62198 PMID:3047366 |
| | A 62198 Preparation Products And Raw materials |
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