- Methotrexate disodium
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- $128.00 / 500mg
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2026-03-05
- CAS:7413-34-5
- Min. Order:
- Purity: 99.96%
- Supply Ability: 10g
- Methotrexate Disodium
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- $0.00 / 1g
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2025-09-11
- CAS:7413-34-5
- Min. Order: 1g
- Purity: More Than 99%
- Supply Ability: 100kg/Month
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| | Methotrexate disodium salt Basic information |
| Product Name: | Methotrexate disodium salt | | Synonyms: | Disodium N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate;sodium methotrexate;L-Glutamic acid, N-4-(2,4-diamino-6-pteridinyl)methylmethylaminobenzoyl-, disodium salt;METHOTREXATUM;2-[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]aminopentanedioic acid;(+)-N-[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt;(+)-N-[4-[[(2,4-Diaminopteridine-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt;4-amino-n(sup10)-methylpteroylglutamicaciddisodiumsalt | | CAS: | 7413-34-5 | | MF: | C20H23N8NaO5 | | MW: | 478.44 | | EINECS: | 231-022-0 | | Product Categories: | Anti-cancer&immunity;API;Molecular biology Products | | Mol File: | 7413-34-5.mol |  |
| | Methotrexate disodium salt Chemical Properties |
| Boiling point | 823℃ | | RTECS | MA1232000 | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | DMSO (Slightly), Water (Slightly) | | form | Powder | | color | Light yellow to yellow | | Water Solubility | Soluble in water | | Sensitive | Hygroscopic | | InChIKey | MSDCZRQHAGWZSH-NVZXTOETNA-N | | SMILES | NC1=NC(N)=NC2N=CC(CN(C3C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=3)C)=NC1=2.[NaH] |&1:19,r| |
| WGK Germany | WGK 3 | | HazardClass | 6.1 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Irrit. 2
Muta. 2
Repr. 1B
Skin Irrit. 2 |
| | Methotrexate disodium salt Usage And Synthesis |
| Uses | Inhibits the metabolism of folic acid | | Definition | ChEBI: Methotrexate disodium is an organic sodium salt that is the disodium salt of methotrexate. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor. It contains a methotrexate(2-). | | Biological Activity | Methotrexate disodium salt is a potent is a folic acid antagonist th at is used as an antineoplastic and antirheumatic drug. Methotrexate disodium salt is a potent inhibitor of dihydrofolate reductase. | | in vivo | Methotrexate (Amethopterin) disodium reduces thymus and spleen indices of mice. Methotrexate disodium markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice[2].
Methotrexate (MTX) disodium (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate disodium (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[4]. | | IC 50 | Traditional Cytotoxic Agents |
| | Methotrexate disodium salt Preparation Products And Raw materials |
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