Tubulin inhibitor 33

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Tubulin inhibitor 33 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:Tubulin inhibitor 33
CAS:2944462-67-1
Package:50mg;1980USD|100mg;2500USD|25mg;1520USD
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
Email: klq@cw-bio.com
Products Intro: Product Name:Tubulin inhibitor 33
CAS:2944462-67-1
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
Company Name: Nantong Hanfang Biotechnology Co. , Ltd.  
Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Products Intro: CAS:2944462-67-1
Purity:98% HPLC Package:10mg;1g;10g;100g;1kg
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:Tubulin inhibitor 33
CAS:2944462-67-1
Package:1removed

Tubulin inhibitor 33 manufacturers
Tubulin inhibitor 33 Basic information
Product Name:Tubulin inhibitor 33
Synonyms:Tubulin inhibitor 33;3H-Imidazo[4,5-c]pyridine, 2-(1-methyl-1H-indol-4-yl)-4-(3,4,5-trimethoxyphenyl)-
CAS:2944462-67-1
MF:C24H22N4O3
MW:414.46
EINECS:
Product Categories:
Mol File:2944462-67-1.mol
Tubulin inhibitor 33 Structure
Tubulin inhibitor 33 Chemical Properties
Boiling point 651.899±65.00 °C(Press: 760.00 Torr)(predicted)
density 1.307±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka10.717±0.40(predicted)
Safety Information
MSDS Information
Tubulin inhibitor 33 Usage And Synthesis
UsesTubulin inhibitor 33, a tubulin polymerization inhibitor, inhibits tubulin polymerization in a dose-dependent manner with an IC50 of 9.05 μM. Tubulin inhibitor 33 has antitumor effects and induces cell apoptosis that can be used for antitumor research[1].
in vivo

Tubulin inhibitor 33 (Compound 3a) (5 mg/kg; i.p. everyday for 14 days) significantly inhibits melanoma tumor growth with tumor growth inhibition (TGI) of 62.96%[1].

Animal Model:B16-F10 melanoma model in C57 mice[1]
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Significantly inhibited melanoma tumor growth with a TGI of 62.96%.
References[1] Ren Y, et.al. X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma. J Med Chem. 2023 May 25;66(10):6697-6714. DOI:10.1021/acs.jmedchem.3c00011
Tubulin inhibitor 33 Preparation Products And Raw materials
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