- 2-Hydroxy-3-cyanopyridine
-
- $200.00 / 1KG
-
2025-09-25
- CAS:20577-27-9
- Min. Order: 1KG
- Purity: 99%, 99.5% Sublimated
- Supply Ability: g-kg-tons, free sample is available
|
| | 2-Hydroxy-3-cyanopyridine Basic information |
| | 2-Hydroxy-3-cyanopyridine Chemical Properties |
| Melting point | 90-94 | | Boiling point | 352.3±35.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in dimethyl sulfoxide. | | form | Solid | | pka | 8.93±0.10(Predicted) | | InChI | InChI=1S/C6H4N2O/c7-4-5-2-1-3-8-6(5)9/h1-3H,(H,8,9) | | InChIKey | DYUMBFTYRJMAFK-UHFFFAOYSA-N | | SMILES | C1(=O)NC=CC=C1C#N | | CAS DataBase Reference | 20577-27-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 22-41 | | Safety Statements | 26-39 | | RIDADR | UN3439 | | Hazard Note | Irritant/Keep Cold | | HazardClass | 6.1 | | HS Code | 2933399990 |
| | 2-Hydroxy-3-cyanopyridine Usage And Synthesis |
| Chemical Properties | Dark Yellow Solid | | Uses | 2-Hydroxy-3-cyanopyridine (cas# 20577-27-9) is a compound useful in organic synthesis. | | Definition | ChEBI: 3-cyano-2-pyridone is a member of pyridines and a nitrile. | | Synthesis | The general procedure for the synthesis of 2-oxo-1,2-dihydropyridine-3-carbonitrile from 2-chloro-3-cyanopyridine was as follows: acetic acid (826 mL) was slowly added to 2-chloro-3-cyanopyridine (250 g), and the mixture was subsequently heated to reflux and held for 48 hours. Upon completion of the reaction, the reaction mixture was quenched by careful pouring into an ice-water mixture. The resulting precipitate was collected by filtration, washed well with deionized water and dried under appropriate conditions to give the target product 2-hydroxy-3-cyanopyridine. The yield of this step was 95%. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 12.57 (s, 1H), 8.16 (dd, J = 3.6 Hz, 1H), 7.80 (dd, J = 3.6 Hz, 1H), 6.37 (t, 1H); the mass spectrum (ES) showed m/z of 121. | | References | [1] Tetrahedron Letters, 2004, vol. 45, # 35, p. 6633 - 6636
[2] Patent: WO2014/207508, 2014, A1. Location in patent: Page/Page column 55
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 18, p. 7624 - 7643
[4] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 21, p. 5738 - 5746
[5] Synthetic Communications, 2011, vol. 41, # 19, p. 2859 - 2869 |
| | 2-Hydroxy-3-cyanopyridine Preparation Products And Raw materials |
|