5-FLUORO-2-THIOPHENECARBOXYLIC ACID manufacturers
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| | 5-FLUORO-2-THIOPHENECARBOXYLIC ACID Basic information |
| Product Name: | 5-FLUORO-2-THIOPHENECARBOXYLIC ACID | | Synonyms: | 5-FLUORO-2-THIOPHENECARBOXYLIC ACID;AKOS B029946;5-Fluoro-thiophene-2-carb...;2-Thiophenecarboxylicacid, 5-fluoro-;5-Fluorothiophen-2-carboxylic acid;4-fluorothiophene-2-carboxylic acid;4-fluorothiop;5-Fluoro-thiophene-2-carboxylic acid | | CAS: | 4377-58-6 | | MF: | C5H3FO2S | | MW: | 146.14 | | EINECS: | | | Product Categories: | | | Mol File: | 4377-58-6.mol |  |
| | 5-FLUORO-2-THIOPHENECARBOXYLIC ACID Chemical Properties |
| Melting point | 139-141℃ | | Boiling point | 271.2±20.0 °C(Predicted) | | density | 1.527±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 3.52±0.10(Predicted) | | Appearance | Off-white to yellow Solid | | InChI | InChI=1S/C5H3FO2S/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H,7,8) | | InChIKey | XQURBTZGKJENJS-UHFFFAOYSA-N | | SMILES | C1(C(O)=O)SC(F)=CC=1 |
| | 5-FLUORO-2-THIOPHENECARBOXYLIC ACID Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 5-fluorothiophene-2-carboxylic acid from 5-fluorothiophene-2-carbonitrile: 138 mg (1.07 mmol) of 5-fluorothiophene-2-carbonitrile and 5 ml of 1N sodium hydroxide solution were added to an eggplant flask, and the mixture was heated and stirred in an oil bath at 100 °C for 2 hours. After completion of the reaction, the reaction solution was cooled to room temperature. Subsequently, 5 ml of water was added to the reaction solution for dilution and the pH was adjusted with 10 ml of 1N hydrochloric acid to 1. Next, the mixture was extracted twice with 30 ml of dichloromethane. The organic layers were combined and dried with anhydrous sodium sulfate. Finally, the solvent was removed by concentration under reduced pressure to give 110 mg of 5-fluorothiophene-2-carboxylic acid. | | References | [1] Patent: US6043379, 2000, A
[2] Patent: US6096901, 2000, A
[3] Patent: US2013/137730, 2013, A1. Location in patent: Paragraph 0092 |
| | 5-FLUORO-2-THIOPHENECARBOXYLIC ACID Preparation Products And Raw materials |
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