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| 2,4-Dichloropyrido[3,2-d]pyrimidine Basic information |
Product Name: | 2,4-Dichloropyrido[3,2-d]pyrimidine | Synonyms: | 2,4-dichloropyrido[3,2-d]pyrimidine;4-dichloropyrido[3;5,6-DIMETHYLPYRAZI...;Pyrido[3,2-d]pyrimidine, 2,4-dichloro-;2,4-Dichloropyrido[3,2-d]pyrimidine ISO 9001:2015 REACH | CAS: | 39551-54-7 | MF: | C7H3Cl2N3 | MW: | 200.02 | EINECS: | | Product Categories: | Heterocycle-Pyrimidine series;CHIRAL CHEMICALS | Mol File: | 39551-54-7.mol | ![2,4-Dichloropyrido[3,2-d]pyrimidine Structure](CAS/GIF/39551-54-7.gif) |
| 2,4-Dichloropyrido[3,2-d]pyrimidine Chemical Properties |
Melting point | 168-169 ºC | density | 1.573 | storage temp. | Inert atmosphere,Store in freezer, under -20°C | pka | -1.31±0.30(Predicted) | Appearance | Off-white to yellow Solid | InChI | InChI=1S/C7H3Cl2N3/c8-6-5-4(2-1-3-10-5)11-7(9)12-6/h1-3H | InChIKey | UVVFNZJVLRJSMW-UHFFFAOYSA-N | SMILES | C1(Cl)=NC(Cl)=C2N=CC=CC2=N1 |
Hazard Codes | T | Risk Statements | 25 | Safety Statements | 45 |
| 2,4-Dichloropyrido[3,2-d]pyrimidine Usage And Synthesis |
Synthesis | 2,4-Dichloropyrido[3,2-d]pyrimidine was synthesized using 2,4-dihydroxypyrido[3,2-d]pyrimidine as starting material in the following steps:
(2) Intermediate B3 (lg) was mixed with phosphorus oxychloride (POCl3) and phosphorus pentachloride (PCl5) and reacted by refluxing at 135°C to obtain intermediate C3 in 48% yield.
The reaction equation was as follows: | References | [1] Synlett, 2006, # 12, p. 1938 - 1942 [2] Patent: CN106083742, 2016, A. Location in patent: Paragraph 0185; 0188; 0189 [3] Journal of the American Chemical Society, 1956, vol. 78, p. 973,974 [4] Journal of the Chemical Society, 1956, p. 1045,1053 [5] Patent: WO2010/37765, 2010, A2. Location in patent: Page/Page column 61 |
| 2,4-Dichloropyrido[3,2-d]pyrimidine Preparation Products And Raw materials |
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