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| | Norfloxacin hydrochloride Basic information |
| Product Name: | Norfloxacin hydrochloride | | Synonyms: | 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride;Norfloxacin hydrochloride;Norfloxacin hydrochloride (1:x);3-Quinolinecarboxylicacid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, hydrochloride(1:);Norfloxacin Hydrochloride For Injection;Hydrochloric acid norfloxacin;1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid,hydrochloride;Nofloxacin Hydrochloride | | CAS: | 104142-93-0 | | MF: | C16H18FN3O3.HCl | | MW: | 355.79 | | EINECS: | 213-535-1 | | Product Categories: | Pharmacutical raw materials | | Mol File: | 104142-93-0.mol |  |
| | Norfloxacin hydrochloride Chemical Properties |
| Melting point | 220 °C | | solubility | insoluble in EtOH; ≥27.3 mg/mL in H2O; ≥5.05 mg/mL in DMSO with gentle warming | | form | powder | | color | white to beige | | InChI | InChI=1S/C16H18FN3O3.ClH/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20;/h7-9,18H,2-6H2,1H3,(H,22,23);1H | | InChIKey | JJWDELPVPRCLQN-UHFFFAOYSA-N | | SMILES | C12C=C(C(F)=CC=1C(=O)C(C(=O)O)=CN2CC)N1CCNCC1.Cl |
| | Norfloxacin hydrochloride Usage And Synthesis |
| Biological Activity | norfloxacin hydrochloride is a broad-spectrum antibiotic that is active against both gram-positive and gram-negative bacteria, which functions by inhibiting dna gyrase. | | in vitro | Norfloxacin hydrochloride (MK-0366 hydrochloride) is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.There are currently three approved uses in the adult population (one of which is restricted) and the other ineffective due to bacterial resistance. |
| | Norfloxacin hydrochloride Preparation Products And Raw materials |
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