5-HT2A/5-HT2C inverse agonist 1

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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
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Products Intro: Product Name:5-HT2A/5-HT2C inverse agonist 1
CAS:2718990-76-0
Package:50mg/RMB 22800
Company Name: Biorbyt Ltd.  
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Products Intro: Product Name:5-HT2A/5-HT2C inverse agonist 1
CAS:2718990-76-0
5-HT2A/5-HT2C inverse agonist 1 Basic information
Product Name:5-HT2A/5-HT2C inverse agonist 1
Synonyms:5-HT2A/5-HT2C inverse agonist 1;Urea, N-[(8S)-5-methyl-5-azaspiro[2.5]oct-8-yl]-N-[(1-methyl-1H-pyrazol-3-yl)methyl]-N′-[(4-propoxyphenyl)methyl]-
CAS:2718990-76-0
MF:C24H35N5O2
MW:425.57
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Mol File:2718990-76-0.mol
5-HT2A/5-HT2C inverse agonist 1 Structure
5-HT2A/5-HT2C inverse agonist 1 Chemical Properties
Boiling point 647.656±55.00 °C(Press: 760.00 Torr)(predicted)
density 1.206±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka13.383±0.46(predicted)
Safety Information
MSDS Information
5-HT2A/5-HT2C inverse agonist 1 Usage And Synthesis
Uses5-HT2A/5-HT2C inverse agonist 1 is a potent and dual 5-HT2A and 5-HT2C receptor inverse agonist with a hERG inhibitions, thus avoiding cardiovascular risks. 5-HT2A/5-HT2C inverse agonist 1 shows significant antipsychotic efficacy in the MK-801 (HY-15084B)-induced mouse model. 5-HT2A/5-HT2C inverse agonist 1 is promising for research of psychosis[1].
References[1] Oguma T, et al. Dual 5-HT2A and 5-HT2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis. J Med Chem. 2024 Aug 22;67(16):14478-14492. DOI:10.1021/acs.jmedchem.4c01244
5-HT2A/5-HT2C inverse agonist 1 Preparation Products And Raw materials
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