| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
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| | RET/TRKA-IN-1 Basic information |
| Product Name: | RET/TRKA-IN-1 | | Synonyms: | RET/TRKA-IN-1;Benzeneacetamide, N-[3-(1,1-dimethylethyl)-1-methyl-1H-pyrazol-5-yl]-4-[[7-(1-methyl-1H-pyrazol-4-yl)-9H-pyrimido[4,5-b]indol-4-yl]amino]- | | CAS: | 3048634-52-9 | | MF: | C30H31N9O | | MW: | 533.63 | | EINECS: | | | Product Categories: | | | Mol File: | 3048634-52-9.mol |  |
| | RET/TRKA-IN-1 Chemical Properties |
| Boiling point | 855.4±65.0 °C(predicted) | | density | 1.34±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 12.38±0.50(predicted) |
| | RET/TRKA-IN-1 Usage And Synthesis |
| Uses | RET/TRKA-IN-1 (Compound 13) is a dual inhibitor for RET (IC50=0.375 μM) and TRKA. RET/TRKA-IN-1 inhibits cell viability of LC-2 and KM12, with GI50 of 0.72 and 0.25 μM. RET/TRKA-IN-1 arrests the cell cycle at G1 phase[1]. | | References | [1] Acharya B, et al., Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors. Bioorg Med Chem. 2024 May 15;106:117749. DOI:10.1016/j.bmc.2024.117749 |
| | RET/TRKA-IN-1 Preparation Products And Raw materials |
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