- 2-Chloro-3-iodopyridine
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- $0.00 / 1kg
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2026-04-30
- CAS:78607-36-0
- Min. Order: 1kg
- Purity: 99.83%
- Supply Ability: 1000kg
- 2-Chloro-3-iodopyridine
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- $0.00 / 25kg
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2025-12-01
- CAS:78607-36-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
- 2-Chloro-3-iodopyridine
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- $1.10 / 1g
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2025-11-18
- CAS:78607-36-0
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons min
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| | 2-Chloro-3-iodopyridine Basic information |
| | 2-Chloro-3-iodopyridine Chemical Properties |
| Melting point | 90-95 °C | | Boiling point | 261.2±20.0 °C(Predicted) | | density | 2.052±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform, Ethyl Acetate | | form | Crystalline Powder | | pka | -0.70±0.10(Predicted) | | color | Cream yellow to salmon | | Sensitive | Light Sensitive | | BRN | 4243304 | | InChI | InChI=1S/C5H3ClIN/c6-5-4(7)2-1-3-8-5/h1-3H | | InChIKey | OHWSWGXNZDSHLM-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=CC=C1I | | CAS DataBase Reference | 78607-36-0(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 36/37/38-20/22-41-22 | | Safety Statements | 36/37/39-26-22-36-39-37 | | WGK Germany | 3 | | Hazard Note | Irritant/Light Sensitive | | HazardClass | IRRITANT | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1 |
| | 2-Chloro-3-iodopyridine Usage And Synthesis |
| Chemical Properties | Off-white Cryst | | Uses | 2-Chloro-3-iodopyridine is a compound useful in organic synthesis. | | Uses | 2-Chloro-3-iodopyridine (cas# 78607-36-0) is a compound useful in organic synthesis. | | Synthesis | General procedure for the synthesis of 2-chloro-3-iodopyridine from 2-chloropyridine: 2,2,6,6-tetramethylpiperidine (17 mL, 14 g, 0.1 mol) and 2-chloropyridine (9.5 mL, 11.5 g, 0.1 mol) were sequentially added to a hexane solution of 1.6 M n-butyllithium (62.5 mL, 0.1 mol) at -78 °C with a solvent of 150 mL of tetrahydrofuran. After maintaining the reaction temperature at -78 °C with stirring for 2 h, a tetrahydrofuran solution (50 mL) of iodine (25.5 g, 0.1 mol) was added dropwise to the reaction mixture and stirring was continued for 30 min. Subsequently, the reaction mixture was partitioned between water (100 mL) and ether (3 x 50 mL). The organic layers were combined, washed with saturated aqueous sodium thiosulfate solution (2 x 50 mL), dried over anhydrous magnesium sulfate, filtered and concentrated in vacuum to give the crude product. The crude product was purified by fast chromatography (eluent: heptane/ethyl acetate, 90/10) to give a yellow solid product in 72% yield (17.3 g). The structure of the product was analyzed by 1H NMR (CDCl3): δ 8.38 (dd, J = 4.6/1.7 Hz, 1H), 8.16 (dd, J = 8.0/0.16 Hz, 1H), 6.96 (dd, J = 8.0/4.6 Hz, 1H); 13C NMR (CDCl3): δ 154.5, 148.9, 148.8, 123.2 , 94.9; MS (EI) m/z 240 (M + 1) confirmed. | | References | [1] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 5, p. 1397 - 1401
[3] Patent: WO2004/52880, 2004, A1. Location in patent: Page 29-30
[4] Tetrahedron Letters, 1994, vol. 35, # 35, p. 6489 - 6492
[5] Organic letters, 2002, vol. 4, # 13, p. 2201 - 2203 |
| | 2-Chloro-3-iodopyridine Preparation Products And Raw materials |
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