- 1,2-Bis(tosyloxy)ethane
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- $0.00 / 25kg/ drum
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2026-02-15
- CAS:6315-52-2
- Min. Order: 25kg/ drum
- Purity: 99%
- Supply Ability: 10 tons
- Tos-PEG2-Tos
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- $0.00 / 500g
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2025-06-07
- CAS:6315-52-2
- Min. Order: 500g
- Purity: >98.00%
- Supply Ability: 500g
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| | 1,2-BIS(TOSYLOXY)ETHANE Basic information |
| Product Name: | 1,2-BIS(TOSYLOXY)ETHANE | | Synonyms: | 1,2-Bis(4-methylbenzenesulfonyloxy)ethane;1,2-Bis(p-tolylsulfonyloxy)ethane;1,2-Di(tosyloxy)ethane;1,2-Ethanediol 1,2-bis(4-methylbenzenesulfonate):1,2-Ethanediol:1,2-bis(4-methylbenzenesulfonate);1,2-Ethanediol ditosylate;1,2-Ethylene ditosylate;Di-O-tosylglycol;Ethylene 1,2-bis(tosylate) | | CAS: | 6315-52-2 | | MF: | C16H18O6S2 | | MW: | 370.44 | | EINECS: | | | Product Categories: | | | Mol File: | 6315-52-2.mol |  |
| | 1,2-BIS(TOSYLOXY)ETHANE Chemical Properties |
| Melting point | 124-127 °C(lit.) | | Boiling point | 544.3±38.0 °C(Predicted) | | density | 1.326 | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly, Heated) | | form | Solid | | color | White to Off-White | | Water Solubility | Slightly soluble in water. | | BRN | 2399520 | | InChI | InChI=1S/C16H18O6S2/c1-13-3-7-15(8-4-13)23(17,18)21-11-12-22-24(19,20)16-9-5-14(2)6-10-16/h3-10H,11-12H2,1-2H3 | | InChIKey | LZIPBJBQQPZLOR-UHFFFAOYSA-N | | SMILES | C(OS(C1=CC=C(C)C=C1)(=O)=O)COS(C1=CC=C(C)C=C1)(=O)=O | | CAS DataBase Reference | 6315-52-2(CAS DataBase Reference) | | EPA Substance Registry System | 1,2-Ethanediol, bis(4-methylbenzenesulfonate) (6315-52-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | HS Code | 2905.31.0000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 1,2-BIS(TOSYLOXY)ETHANE Usage And Synthesis |
| Chemical Properties | Colourless solid | | Uses | Ethylene di(p-toluenesulfonate) [Ethylene glycol ditosylate] has been used in the synthesis of, cyclohexyl-fused 1,4,7-triazacyclononane, 1,2-ethylenecalix[6]arene, 1,3- and 1,4-calix[6]crown-3, 1,3- and 1,4-calix[6]crown-4, 1,4-calix[6]benzocrown-4, 1,2- and 1,3-calix[6]crown-5. | | Synthesis | The general procedure for the synthesis of 1,2-bis(tolyloxy)ethane from ethylene glycol and p-toluenesulfonyl chloride was as follows: 19.8 g (0.3 mol) of ethylene glycol was dissolved in 150 mL of distilled pyridine, and the solution was subsequently cooled in an ice bath. Under mechanical stirring, p-toluenesulfonyl chloride (123 g, 0.65 mol) was slowly added and it was ensured that the reaction temperature was maintained below 20°C during the addition. When approximately 90 g of p-toluenesulfonyl chloride was added, stirring was difficult due to the increased viscosity of the mixture, at which point 200 mL of pyridine was added for dilution. Stirring of the reaction mixture was continued for 2 hours and 30 minutes. Upon completion of the reaction, an aqueous HCl solution consisting of 12 N HCl (170 mL) and ice (500 mL) was added to the mixture. The solid formed in the process was removed by filtration. The resulting solid was dissolved in 250 mL of refluxing methanol and subsequently filtered to remove the newly formed precipitate after cooling to room temperature. Finally, the obtained white solid was dried under vacuum to give the pure product 1,2-bis-toluoxyethane (92.4 g, 83% yield). The product was characterized as follows: 1H NMR (200 MHz, CDCl3) δ 7.71 (d, 2H), 7.31 (d, 2H), 4.16 (s, 2H), 2.43 (s, 3H). | | References | [1] Journal of Organic Chemistry, 1992, vol. 57, # 24, p. 6678 - 6680
[2] Synthetic Communications, 1995, vol. 25, # 14, p. 2037 - 2042
[3] Macromolecular Bioscience, 2014, vol. 14, # 12, p. 1807 - 1815
[4] Tetrahedron Letters, 2001, vol. 42, # 50, p. 8781 - 8783
[5] Journal of the Chinese Chemical Society, 2004, vol. 51, # 5 B, p. 1201 - 1208 |
| | 1,2-BIS(TOSYLOXY)ETHANE Preparation Products And Raw materials |
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